12 results
Osteoarthritis (OA): Clinical findings
 • Stimulation of joint nociceptors in subchondral bone -> Pain with loading
in subchondral bone ... production -> Joint effusion ... Osteoarthritis #OA #pathophysiology ... #diagnosis #signs ... #symptoms #complications
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
Most cases diagnosed ... collection with EDTA Pathophysiology ... mineralization Symptoms ... respiratory failure • Neurologic ... Difficulty walking Diagnosis
Shock - Diagnosis and Management Summary
 • Hypotension: SBP<90, SBP drop >40, MAP<65 (Normotension, HTN possible
Shock - Diagnosis ... Consider IL NS/LR infusion ... Setup - Ultrasound ... #Shock #Diagnosis ... Management #Summary #criticalcare
Rheumatoid arthritis (RA): Pathogenesis and Joint diseases features
 • RA affects 1% of population, women >
in subchondral bone ... Palpable Joint effusion ... RheumatoidArthritis #RA #pathophysiology ... #signs #symptoms ... #diagnosis
Pseudogout: pathogenesis and clinical findings
 - Idiopathic (vast majority of cases) -> Mechanism unknown
 - Familial
phosphorous in bones ... high-resolution ultrasound ... Disease #Signs #Symptoms ... #Pathophysiology ... #Diagnosis
Posterior Reversible Encephalopathy Syndrome (PRES) Overview

Clinico-Radiological Syndrome, characterized by:
 • Headache
 • Seizures
 • Altered mental
may precede the neurologic ... Transplantation including bone ... Etiology: • Pathophysiology ... Neurological symptoms ... #management #neurology
Myasthenic Crisis Checklist - Myasthenia Gravis

Evaluation 
 - Chest X-ray and lung ultrasound (exclude other lung
X-ray and lung ultrasound ... or TSH level if symptoms ... Pyridostigmine - New diagnosis ... to avoid (main ones ... Checklist #Management #CriticalCare
Guillain-Barré Syndrome (GBS)
Acute autoimmune demyelinating polyradiculoneuropathy that presents with rapidly progressive flaccid weakness
Epidemiology:
 • Incidence: 1
surgery, trauma, and bone-marrow ... bulbar muscles DIAGNOSIS ... than one after symptom ... the underlying pathophysiology ... #management #neurology
Charcot Joint - Neuropathic Arthropathy: Pathogenesis and Clinical findings
 • Impaired joint protection -> abnormal joint
erythema, joint effusion ... periarticular bone ... #Arthropathy #pathophysiology ... #diagnosis #signs ... #symptoms
Severe Influenza Checklist

Diagnostic tests 
 - Blood cultures x2 
 - Sputum gram stain & culture
Influenza Checklist Diagnostic ... function tests - Ultrasound ... needed to exclude effusion ... BID if <96hr of symptoms ... Checklist #Management #CriticalCare