13 results
Aplastic Anemia - Illness Script
Signs and symptoms:
 • Recurrent infections from neutropenia
 • Mucosal bleeding from
Aplastic Anemia ... infections from neutropenia ... antibiotics if neutropenic ... fever) Complications ... management #treatment #hematology
Causes of Neutropenia with Pancytopenia - Differential Diagnosis Algorithm
Sequestration:
 • Splenomegaly
Marrow Infiltration:
 • Hematologic and non-hematologic
Causes of Neutropenia ... Differential Diagnosis Algorithm ... Toxins • Aplastic Anemia ... #Pancytopenia #Neutropenia ... #Causes #Hematology
Hemophagocytic Lymphohistiocytosis (HLH)
Clinical Features: Fever, Splenomegaly, Hepatomegaly, Lymphadenopathy, Confusion
Classic lab findings in HLH: ↑↑ ferritin, Anemia,
Clinical Features: Fever ... : ↑↑ ferritin, Anemia ... Thrombocytopenia, Neutropenia ... 8 criteria: • Fever ... Lymphohistiocytosis #diagnosis #hematology
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Aplastic Anemia ... Presentation: • Fever ... Difficulty breathing • Neutropenia ... recurrent infections/fevers ... #oncology #hematology
Hematology Algorithms 

Anemia is described as a reduction in the proportion of the red blood cells.
Hematology Algorithms ... Anemia is described ... symptoms related to anemia ... on whether the anemia ... primarily seen as neutropenia
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Differential Diagnosis Algorithm ... bartonella (oroya fever ... ARUPLabs #Hemolytic #Anemia ... #workup #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary
Overview: 
 • Most common leukemia in adults
 • Disorder of
) B symptoms → fevers ... 5) Symptoms of anemia ... PRCA, autoimmune neutropenia ... marrow failure with anemia ... Leukemia #oncology #hematology
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
Lymphadenopathy • Fevers ... Cytopenias: • Neutropenia ... , anemia, thrombocytopenia ... workup #oncology #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
Headaches, bone pain, fever ... - infiltrates (anemia ... or functional neutropenia ... Lymphadenopathy • HSM • Fevers ... #Leukemia #Hematology
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
blood cell count (anemia ... (petechiae) • Frequent ... • Aplastic Anemia ... Myeloproliferative Disease • Neutropenia ... Syndromes #diagnosis #hematology