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Nephron Pathophysiology Study Guide 

- Proximal Tubule
- Loop of Henle
- Distal Tubule
- Collecting Duct

The Kidney Zone

#Nephron
Nephron Pathophysiology ... - Proximal Tubule ... Henle - Distal Tubule ... Nephron #Nephrology #Pathophysiology ... #Overview #Tubules
Nephron Physiology
 - Proximal Convoluted Tubule
 - Thick Ascending Limb
 - Distal Convoluted Tubule
 - Ion
Proximal Convoluted Tubule ... Distal Convoluted Tubule ... in Collecting Tubule ... in Collecting Tubule ... #Nephron #Pathophysiology
Localization of Renal Tubular Defects
Fanconi Syndrome: Proximal tubule
Bartter Syndrome: Thick ascending loop of Henle
Gitelman Syndrome: Distal
Localization of Renal Tubular ... Syndrome: Proximal tubule ... Distal convoluted tubule ... Syndrome: Collecting tubule ... Nephron #Defects #Pathophysiology
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
distal convoluted tubule ... (DCT) Clinical ... syndrome, Renal tubular ... nephrology #management #pathophysiology
Nephron Schematic Map - Colombia Nephrology

#Nephron #Nephrology #Pathophysiology #Overview #Tubules #Duct #LoopOfHenle #Diuretics #Schematic #Map
Nephron #Nephrology #Pathophysiology ... #Overview #Tubules
Major Segments of the Nephron and their Functions 
 - Glomerulus - Formation of glomerular filtrate
Proximal convoluted tubule ... - Proximal tubule ... Distal convoluted tubule ... Segments #Function #Pathophysiology ... #Tubules #Table
Nephron Physiology and Transporters
 • Proximal Tubule
 • Thick Ascending Limb
 • Distal Convoluted Tubule
 •
Transporters • Proximal Tubule ... Distal Convoluted Tubule ... Duct #Nephron #pathophysiology
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
Phosphatase Of Clinical ... proximal convoluted tubule ... Neuropathy ALP is critical ... collection with EDTA Pathophysiology
Nephron Reabsorption Sites
 • Proximal Convoluted Tubule
 • Proximal Straight Tubule
 • Thick Ascending Limb
 •
Proximal Convoluted Tubule ... Proximal Straight Tubule ... Distal Convoluted Tubule ... #Reabsorption #pathophysiology
Hyperuricemia: Pathogenesis and Complications

 - Hypercalcemia (due to diseases like Sarcoidosis and Hyperparathyroidism) -> Accumulation of
calcium in renal tubules ... from the blood - Tubular ... distal convoluted tubule ... Hyperuricemia #Pathophysiology