10 results
Bilirubin Metabolism - Pathophysiology
 • Conjugated Bilirubin
 • Unconjugated Bilirubin

By Dr. Khushboo Gala @LouLectures

#Bilirubin #Metabolism #Pathophysiology
Bilirubin Metabolism ... - Pathophysiology ... • Conjugated Bilirubin ... #Metabolism #Pathophysiology ... #hepatology #Liver
Biochemistry and Metabolism of Bilirubin
Hemolysis → Hemoglobin → Heme → Biliverdin → Unconjugated Bilirubin (a.k.a. "indirect
Metabolism of Bilirubin ... → Unconjugated Bilirubin ... "indirect bilirubin ... Biochemistry #Metabolism #pathophysiology ... #hepatology
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism
AST and ALT:
 • AST: liver
Phosphatase and Bilirubin ... initial insult Bilirubin ... transports conjugated bilirubin ... ASTALT #AlkPhos #Bilirubin ... #Hepatology #Pathophysiology
Bilirubin metabolism and pathophysiology of jaundice 

#Bilirubin #metabolism #pathophysiology #jaundice #hepatology
Bilirubin metabolism ... and pathophysiology ... of jaundice #Bilirubin ... #metabolism #pathophysiology ... #jaundice #hepatology
Inherited Non-hemolytic Disorders of Hyperbilirubinemia 

== Disorders of Conjugation ==
Gilbert Syndrome:
 • 5-10% of the population
birth with serum bilirubin ... associated with bilirubin ... in conjugated bilirubin ... Hyperbilirubinemia #Inherited #Congenital ... #bilirubin #hepatology
Overall Approach to Anemia - Differential Diagnosis Algorithm

Blood Loss
 • Acute Bleed - Normocytic / Normochromic
Increased Unconjugated Bilirubin ... Spherocytes on Smear - Congenital ... Algorithm #Causes #Hematology
Causes of Splenomegaly - Differential Diagnosis Algorithm
Infectious
 • Bacterial
 • Viral (EBV)
 • Parasitic
 • Fungal
Congestive
Viral (EBV) • Parasitic ... Thalassemia • Congenital ... Algorithm #Causes #Hematology
Causes of Biliary Dilatation - Differential Diagnosis
 • Physiological: ↑ Age, Cholecystectomy, Opioid dependence, Post-sphincterotomy
 •
compression • Congenital ... Ampullary stenosis, Parasitic ... differential #diagnosis #hepatology
Inherited forms of Hyperbilirubinemia
Major pathways involved in bilirubin production, conjugation, and excretion. Notes: Both the UB
pathways involved in bilirubin ... transporting unconjugated bilirubin ... Hyperbilirubinemia #pathophysiology ... #congenital #hepatology
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
65 years PBC Pathophysiology ... slightly elevated • Bilirubin ... diagnosis #workup #hepatology