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management dermatology rheumatology differential syndrome hepatology oncology sle clinical erythematosus photo stills summary systemic vasculitis activation adult adultonset antinxp2 antinxp2dm
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
arthritis, Skin rash ... Differential Diaqnoses ... Complications: MAS ... #diagnosis #management ... #treatment #rheumatology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
(SLE) - Diagnosis ... Manifestations: Malar rash ... life-threatening • Treatment ... Evolution: Chronic disease ... Erythematosus #Diagnosis
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Classification: ... Differential Diagnosis ... Malignancy (e.g. hematologic ... erythematosus (NPSLE): • May ... Erythematosus #Diagnosis
Vesiculobullous Rashes - THE ALGORITHMIC APPROACH Vesiculobullous rashes provoke significant angst in many physicians (Figure 5, page
Vesiculobullous Rashes - THE ALGORITHMIC ... disseminated gonococcal disease ... hand-foot-and-mouth disease ... #Diagnosis #Dermatology ... #Algorithm #Differential
Secondary Syphilis Rash Secondary syphilis is the most contagious of all the stages of this disease, and
stages of this disease ... with or without treatment ... , but without treatment ... #Diagnosis #Clinical ... #Photo #Dermatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
• Systemic lupus ... Petechial or purpuric rash ... SJIA], systemic lupus ... Treatment: • Corticosteroids ... Activation #Syndrome #Diagnosis
Petechial/Purpuric Rashes- THE ALGORITHMIC APPROACH These rashes can be especially challenging and are associated with devastating differential
in vasculitic diseases ... disseminated gonococcal disease ... petechial or purpuric rash ... #Diagnosis #Dermatology ... Purpural #Purpuric #Rash
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
NPSLE rare, Malar rash ... Manifestations: Malar rash ... life-threatening • Treatment ... Evolution: Chronic disease ... #diagnosis #management
Erythematous Rashes - THE ALGORITHMIC APPROACH Characterized by diffuse redness of the skin due to capillary congestion, erythematous
includes Kawasaki disease ... erythematous rash ... Nikolsky sign may ... #Diagnosis #Dermatology ... #Erythematous #Rash
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Glomerulonephritis (RPGN) RPGN has ... Post-strep GN, Lupus ... involvement: Anti-GBM Disease ... #differential #diagnosis ... #algorithm #rheumatology
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