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rheumatology differential management causes druginduced erythematosus signs systemic anemia autoantibodies chronic cll comparison dermatology dil disorders hemolytic leukemia lymphocytic mimickers
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Neurological 12% - Thrombocytopenia ... involvement 3% SLE-Related ... Lupusreference #SLE ... autoantibodies #signs #symptoms ... #differential #rheumatology
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
(SLE) General: ... Leucopenia/lymphopenia, Thrombocytopenia ... #Lupus #SLE #systemic ... erythematosus #signs #symptoms ... #diagnosis #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Constitutional symptoms ... • Immunologic Workup ... constitutional symptoms ... • Immunologic Workup ... #diagnosis #management
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- Differential Diagnosis ... and Workup History ... pylori test (GI symptoms ... test, ANA (e.g., SLE ... #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Algorithm • Sickle ... genotypes): SS, SC, SE ... Schistocytes, thrombocytopenia ... #Algorithm #workup ... #hematology #testing
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
- Differential Diagnosis ... Algorithm Pinpoint ... hemostasis: - Thrombocytopenia ... Autoimmune Vasculitis (lupus ... deficiency Work
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
non-Hodgkin lymphoma SLL ... with no early symptoms ... Neutropenia, anemia, thrombocytopenia ... #workup #oncology ... #hematology
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
Constitutional symptoms ... is rare in DIL, SCLE-DIL ... • Immunologic Workup ... #DIL #rheumatology ... #diagnosis #treatment
TAFRO TAFRO syndrome was first described in 2010, standing for: - Thrombocytopenia - Anasarca - Fever - Reticulin fibrosis - Organomegaly TAFRO syndrome
including systemic lupus ... erythematosus (SLE ... and the systemic symptoms ... Histopathological Diagnoses ... agonists #TAFRO #diagnosis
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