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rheumatology hematology blood product reactions syndrome treatment activation adult antinxp2 antinxp2dm cardiology criteria dermatomyositis dress endocarditis macrophage major mas minor
Adult-Onset Still's Disease (AOSD) Rare inflammatory disorder of unknown etiology, difficult to diagnose because of heterogenous presentation.
Disease (AOSD) ... salmon-colored maculopapular ... rash, arthritis ... #Stills #Disease ... #diagnosis #management
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
arthritis, Skin rash ... hepatitis • Pulmonary ... Prunelle Getten #AdultOnset ... #Stills #Disease ... #diagnosis #management
Adult Onset Still's Disease - Yamaguchi Criteria Major criteria: - Fever >= 39C lasting >= 1 weeks
Adult Onset Still's ... : maculopapular, ... polyarteritis nodosa #AdultOnset ... #Stills #Disease ... Yamaguchi #Criteria #Diagnosis
Adult Onset Still's Disease Systemic inflammation with urticarial rash. Rash: • Nonpruritic, evanescent (correlates with time of
Adult Onset Still's ... nonpruritic macular or maculopapular ... #Adult #onset #Stills ... #disease #AOSD ... #management
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Definition: • Severe adverse drug reaction, characterized by
extensive skin rash ... • Maculopapular ... Criteria for Diagnosis ... DRESS #Syndrome #dermatology ... #diagnosis #management
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
• Adult-onset Still ... Petechial or purpuric rash ... erythematosus [SLE], AOSD ... Activation #Syndrome #Diagnosis ... #Management #Hematology
Endocarditis Summary Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV substance use • IV catheter • Recent
Generalized: • Chills ... Cerebral > Splenic, pulmonary ... Differential Diagnosis ... Paradoxical emboli via ASD ... #management #cardiology
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
/sx urticaria, maculopapular ... rash, pruritis, ... Borrellia (Lyme disease ... #Transfusion #diagnosis ... #management #hematology
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
/sx urticaria, maculopapular ... rash, pruritis, ... Borrellia (Lyme disease ... #Transfusions #diagnosis ... #management #hematology
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
But can still have ... (blue-purple) rash ... had more severe disease ... #management #rheumatology ... #dermatology
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