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hematology differential management vasculitis clinical skinrash apml classification comparison dermatologic differentiation erythematosus eschar gpa granulomatosis hand hemophagocytic hlh joint lcv
Skin Conditions Associated with Joint Pain Rash • Human parvovirus B19 infection Malar rash • SLE • Human parvovirus B19 infection •
• Rheumatic fever ... Crohn's disease Palpable ... Sarcoidosis #dermatology ... #differential #diagnosis ... #rheumatology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Differential Diagnosis ... Kasabach-Merritt syndrome ... mountain spotted fever ... #hematology #rheumatology ... #dermatology
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA) Skin involvement in granulomatosis with polyangiitis (GPA) is common and
• Petechiae, Palpable ... Maculopapular rash ... • Goodpasture syndrome ... #rash #diagnosis ... #rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation ... Petechial or purpuric rash ... #Syndrome #Diagnosis ... #Management #Hematology ... #Rheumatology
TRALI vs TACO - Transfusion Reactions TRALI: • Epidemiology: 0.1% of transfused patientsl • Risk factors: Critical
sequestration and activation ... , and CXR with pulmonary ... edema) • Fever ... Transfusion #Reactions #hematology ... #diagnosis #comparison
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
- Differential Diagnosis ... Vasculitis: • Fevers ... and branches • Fever ... , mucositis • Rash ... #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
mucositis - Rash ... Vasculitis: • Fevers ... scleritis • Palpable ... Skin -> causing palpable ... #rheumatology #
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... excessive macrophage activation ... Diagnosis via genetic ... following: • Fever ... management #treatment #hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
weight loss, and fever ... Differential Diagnosis ... to: Arthritis, Fever ... Chronic B-cell activation ... #Rheumatology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Subacute-Acute: • Common: fever ... Imaging: CXR- pulmonary ... Differentiation #Syndrome ... #management #hematology
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