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Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury Hepatocellular Liver Injury • AST/ALT elevation
Liver Enzymes (LFTs ... ) - Causes of Hepatocellular ... and Cholestatic Liver ... value = (ALT + ULN ... phosphatase + ULN
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... Severe ALT > 15x ULN ... Moderate ALT 5-15x ULN ... Mild ALT < 5x ULN ... Diagnosis #Algorithm #Causes
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
intralobular bile ducts causes ... cholestasis → Cirrhosis/Liver ... • ALP > 1.5 x ULN ... or higher • Liver
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
Liver Function Test ... specific for the liver ... Value = (ALT / ULN ... ALT) / (ALP / ULN ... SinaiBmoreIMRes #Liver
Drugs and Classes Associated with DILI and Type of Liver Injury #Medications #Differential #DrugInduced #LiverInjury #Hepatology #Pharmacology
Drugs and Classes ... DILI and Type of Liver ... #Pharmacology #Causes
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 Table of Causes of Acute Liver Injury #Diagnosis #Hepatology #Acute #Liver #Injury #Causes #Differential #Incidence #Table #Failure
Table of Causes ... of Acute Liver Injury ... Hepatology #Acute #Liver ... #Injury #Causes
Drugs Causing Acute Pancreatitis Class Ia: The medications in which there was a rechallenge and other causes
rechallenge and other causes ... out other common causes ... Class II: Cases ... and atleast4 case ... #Pancreatitis #Causes
Causes of Severe Acute Liver Injury - Ichemic hepatitis - Acute biliary obstruction - Drug-Induced liver
Causes of Severe ... Acute Liver Injury ... - Drug-Induced liver ... Severe #Acute #Causes
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
Acute Fatty Liver ... hepatocytes → Liver ... = nonspecific (nausea ... malaise) → Acute liver ... AST/ALT (5-10x ULN
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Liver Chemistries ... R-value: Serum (ALT/ULN ... ALT) / (Alk phos/ULN ... Identify Acute Liver ... - Specific to liver
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