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Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury Hepatocellular Liver Injury • AST/ALT elevation
Liver Enzymes (LFTs ... and Cholestatic Liver ... value = (ALT + ULN ... phosphatase + ULN ... Transaminitis #diagnosis #differential
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... - Differential ... Severe ALT > 15x ULN ... Mild ALT < 5x ULN ... #LiverEnzymes #Differential
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Tests - Differential ... Severe - ALT >15X ULN ... Moderate - ALT 5-15X ULN ... Mild - ALT < 5x ULN
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Liver Chemistries ... R-value: Serum (ALT/ULN ... ALT) / (Alk phos/ULN ... Identify Acute Liver ... chemistry #diagnosis #differential
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
Acute Fatty Liver ... hepatocytes → Liver ... malaise) → Acute liver ... AST/ALT (5-10x ULN ... infiltration) Differential
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
cholestasis → Cirrhosis/Liver ... • ALP > 1.5 x ULN ... or higher • Liver ... bile ducts Differential
Hypertensive Disorders of Pregnancy Chronic Hypertension: • Guidelines as SBP ≥130 or DBP ≥ 90 mmHg •
pits <100k), ↑ liver ... enzymes (2x ULN ... hemolysis, elevated liver ... obstetrics #cardiology #differential
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
Liver Function Test ... specific for the liver ... Value = (ALT / ULN ... ALT) / (ALP / ULN ... SinaiBmoreIMRes #Liver
Liver Mass Differential Diagnosis Solid: • Benign: Hepatic Hemangioma, Focal nodular hyperplasia, Hepatocellular adenoma, Regenerative nodules •
Liver Mass Differential ... Cystadenoma, Polycystic liver ... Echinococcus #Liver ... #Mass #Differential
Radius and Ulna Anatomy By @rev.med #Radius #Ulna #Anatomy #Bones #orthopedics #MSK
Radius and Ulna ... rev.med #Radius #Ulna
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