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diagnosis hematology differential algorithm management clinical causes treatment pathophysiology pocus ultrasound anemia cirrhosis workup hepatic gastroenterology radiology pharmacology syndrome table
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
Liver Function Test ... specific for the liver ... Value = (ALT / ULN ... SinaiBmoreIMRes #Liver ... Transaminitis #diagnosis #hepatology
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury Hepatocellular Liver Injury • AST/ALT elevation
Liver Enzymes (LFTs ... and Cholestatic Liver ... value = (ALT + ULN ... phosphatase + ULN ... #differential #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... Severe ALT > 15x ULN ... Moderate ALT 5-15x ULN ... Mild ALT < 5x ULN ... Others #LFTs #Hepatology
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Severe - ALT >15X ULN ... Moderate - ALT 5-15X ULN ... Mild - ALT < 5x ULN ... Algorithm #diagnosis #hepatology
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
Acute Fatty Liver ... hepatocytes → Liver ... malaise) → Acute liver ... AST/ALT (5-10x ULN ... #Pregnancy #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Liver Chemistries ... R-value: Serum (ALT/ULN ... ALT) / (Alk phos/ULN ... Identify Acute Liver ... #differential #Hepatology
Autoimmune Hepatitis Clinical Presentation - Highly variable clinical presentation, from subclinical disease to acute liver failure. -
disease to acute liver ... hepatocellular pattern of liver ... ALT + AST > 5x ULN ... AND IgG > 2x ULN ... Diagnosis #Management #Hepatology
Hepatitis B - Treatment Indications Treatment not indicated: • Immune tolerant state - HBe-Ag detectable, high HBV
IU/mL and ALT > ULN ... infection with severe liver ... mg/dL) or acute liver ... Indications #management #hepatology
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
cholestasis → Cirrhosis/Liver ... • ALP > 1.5 x ULN ... or higher • Liver ... diagnosis #workup #hepatology
Focused evaluation algorithm for acute liver injury #Liver #Injury #Acute #Evaluation #Algorithm #Diagnosis #Hepatology
algorithm for acute liver ... injury #Liver ... Algorithm #Diagnosis #Hepatology
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