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management diagnosis differential hepatology causes gastroenterology hematology nephrology disease cardiology pulmonary oncology rheumatology neurology guidelines hepatitis syndrome endocrinology ibd pharmacology
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury Hepatocellular Liver Injury • AST/ALT elevation
Liver Enzymes (LFTs ... and Cholestatic Liver ... Hepatocellular Liver ... or Cholestatic Liver ... @AnnKumfer #Liver
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
Liver Function Test ... kidney, brain ALT ... specific for the liver ... / ULN ALT) / (ALP ... SinaiBmoreIMRes #Liver
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Differential Diagnosis Algorithm ... : • Severe - ALT ... >15X ULN ... Transaminitis #Algorithm
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... Differential Diagnosis Algorithm ... Severe ALT > 15x ... ULN • Viral ... Differential #Diagnosis #Algorithm
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Liver Chemistries ... /ULN ALT) / (Alk ... Identify Acute Liver ... than ALT • ALT ... : Specific to liver
Hepatitis B - Treatment Indications Treatment not indicated: • Immune tolerant state - HBe-Ag detectable, high HBV
Hepatitis B - Treatment ... Indications Treatment ... Treatment possibly ... infection with severe liver ... mg/dL) or acute liver
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
Acute Fatty Liver ... hepatocytes → Liver ... Findings: • ↑AST/ALT ... (5-10x ULN), ↑Tbili ... Cr, ↓Glucose, ↓PLT
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Differential Diagnosis Algorithm ... than ALT • ALT ... • AST: ↑ • ALT ... - ALP > AST/ALT ... differential #diagnosis #algorithm
Autoimmune Hepatitis Clinical Presentation - Highly variable clinical presentation, from subclinical disease to acute liver failure. -
disease to acute liver ... hepatocellular pattern of liver ... + AST > 10x ULN ... - ALT + AST > ... regarding need for treatment
Features of Components of Liver Function Tests #Diagnosis #IM #GI #LFTs #Liver #Function #Tests #Locations #AlkPhos
Components of Liver ... #IM #GI #LFTs #Liver ... #AlkPhos #AST #ALT
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