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hyponatremia diagnosis algorithm differential management treatment cancer cerebral comparison hypotonic low oncology pathophysiology physiologic saltwasting table volume
Physiologic Approach to Hypotonic Hyponatremia The next time you have a case of hypotonic hyponatremia, give the
restriction alone in SIADH ... Present (Uosm ≥100): SIADH ... , Renal Sodium loss ... diagnosis #table #sodium ... #nephrology
Management of SIADH Treat underlying cause: • Causes can include pain, primary lung pathology, post-operative phenomenon, medications,
Management of SIADH ... pain, primary lung ... promoting passive sodium ... osmolality < 538 AND UNa ... #hyponatremia #nephrology
Cerebral Salt Wasting vs SIADH - Pathophysiology 1) Neurological event 2) Sodium loss from tubules 3) Naturiesis →
Salt Wasting vs SIADH ... Neurological event 2) Sodium ... reabsorption 5) ↓ Na ... #SaltWasting #SIADH ... Pathophysiology #diagnosis #nephrology
Modified Hyponatremia Algorithm Hypertonic Hyponatremia: Hyperglycemia, Mannitol, Urologic irrigants Hypotonic Hyponatremia: • ADH ON (UOsm > 100):
- RAAS ON (UNa ... - RAAS OFF (UNa ... > 30): SIADH, Medications ... Algorithm #diagnosis #sodium ... #nephrology
SIADH Treatment Options 1. Treat underlying cause of SIADH: Pain, Primary lung pathology, Post-operative phenomenon, Medications, Basically
SIADH Treatment ... Pain, Primary lung ... promoting passive sodium ... osmolality < 538 AND UNa ... #hyponatremia #nephrology
Volume Based Approach to Hyponatremia Hypovolemic, Serum uric acid >4 • Urine Na <20: Extra-renal losses •
acid >4 • Urine Na ... losses • Urine Na ... uric acid <4 • SIADH ... algorithm #diagnosis #sodium ... #low #nephrology
Hyponatremia Differential Diagnosis Algorithm in Cancer UOsm ≥ 100 mOsm/kg = Urine is inappropriately concentrated for hypotonic
Vasopressin-dependent - UNa ... following HSCT) - UNa ... inappropriate • SIAD ... tumors, brain or lung ... Cancer #algorithm #nephrology
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