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diagnosis algorithm differential management cancer comparison hypotonic low oncology osmolality pathophysiology physiologic potomania raas saltwasting table thiazides unaa volume
Cerebral Salt Wasting vs SIADH - Pathophysiology 1) Neurological event 2) Sodium loss from tubules 3) Naturiesis →
Neurological event 2) Sodium ... → ADH → water reabsorption ... 5) ↓ Na+ → Subclinical ... Pathophysiology #diagnosis #nephrology ... #hyponatremia #
Modified Hyponatremia Algorithm Hypertonic Hyponatremia: Hyperglycemia, Mannitol, Urologic irrigants Hypotonic Hyponatremia: • ADH ON (UOsm > 100):
< 30): Hypovolemia ... > 30): SIADH, Medications ... Reset osmostat, Cerebral ... Algorithm #diagnosis #sodium ... #nephrology
Physiologic Approach to Hypotonic Hyponatremia The next time you have a case of hypotonic hyponatremia, give the
or Ineffective (UNa ... (Uosm ≥100): SIADH ... , Renal Sodium loss ... Insufficiency, Cerebral ... #nephrology
Volume Based Approach to Hyponatremia Hypovolemic, Serum uric acid >4 • Urine Na <20: Extra-renal losses •
Hypovolemic, Serum ... Renal losses, Cerebral ... uric acid <4 • SIADH ... algorithm #diagnosis #sodium ... #low #nephrology
Hyponatremia (<135 mEq/L) is a common electrolyte abnormality caused by an excess of total body water
consequence of cerebral ... #hyponatremia #ADH ... #RAAS #Hypovolemia ... #EBV #potomania ... #SIADH #Thiazides
Management of SIADH Treat underlying cause: • Causes can include pain, primary lung pathology, post-operative phenomenon, medications,
promoting passive sodium ... osmolality < 538 AND UNa ... antagonists: • Blocks ADH ... #Management #hyponatremia ... #nephrology #treatment
SIADH Treatment Options 1. Treat underlying cause of SIADH: Pain, Primary lung pathology, Post-operative phenomenon, Medications, Basically
SIADH Treatment ... Pain, Primary lung ... promoting passive sodium ... vaptans) • Blocks ADH ... #nephrology #treatment
Hyponatremia Differential Diagnosis Algorithm in Cancer UOsm ≥ 100 mOsm/kg = Urine is inappropriately concentrated for hypotonic
Hyponatremia Differential ... appropriate • Hypovolemia ... inappropriate • SIAD ... tumors, brain or lung ... Cancer #algorithm #nephrology
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