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Pathophysiology Based Approach to Hyponatremia - Diagnostic Algorithm

Not the "classic" Volume based approach. 

#Hyponatremia #Algorithm #Pathophysiology
Differential #Nephrology #UOsm ... #Osmolality
Causes of Polyuria - Differential Diagnosis Algorithm
Polyuria - Urine Output > 3L/day, Increased Urine Volume (>2ml/min)
Osmotic
Diuresis Urine Osmolality ... > Serum Osmolality ... Loss - DDAVP -> Uosm ... Insipidus - DDAVP -> Uosm
Hyponatremia (<135 mEq/L) is a common electrolyte abnormality caused by an excess of total body water
Measuring the serum osmolality ... concentration and urine osmolality ... fall in serum osmolality ... If Posm >285 mOsm ... (Uosm).
Fluids, Electrolytes, Acid-Base
)
General Concepts
>
< Osmolality vs osmolarity
★
Osmolality
[H 20)
Milliosmoles per kg of water. The osmolality is the
vs osmolarity ... the number of (mOsm ... mole of salt is 1 Osm ... of Na +1 Osm of ... Osmolarity (mOsm
Hyponatremia Diagnosis Algorithm
UOsm ≥ POsm - Vasopressin-Dependent
 • UNa < 20 mEq/L - Appropriate (↓ EABV)
Diagnosis Algorithm UOsm ... ≥ POsm - Vasopressin-Dependent ... Cortisol deficiency UOsm ... < POsm - Vasopressin-independent
Polyuria - Differential Diagnosis Algorithm
Polyuria = >3L Urine output / 24 hours
Urine osmolality = 2 (Na
24 hours Urine osmolality ... /18 HIGH urine osmolality ... > 300 mosm/kg ... Azotemia LOW urine osmolality ... < 100 mosm/kg
Polyuria - Differential Diagnosis Algorithm
Urine Output > 3L /day
Water Diuresis (Urine Osm <100 mOsm/kg)
 • Primary
Diuresis (Urine Osm ... <100 mOsm/kg) ... Diuresis (Urine Osm ... 100-200 mOsm/kg ... 300-500 mOsm/kg
Hypo-osmolar Hypotonic HypoNatremia Algorithm (Serum Na+ < 135 meq/L, serum Osm < 275 mosm/kg)
Assess Volume Status,
135 meq/L, serum Osm ... < 275 mosm/kg) ... Urine Na, Urine Osm
Contrast dyes are divided into three groups based on their osmolarity.  High-osmolar contrast medium (HOCM),
based on their osmolarity ... LowOsmolarity #Osmolality
Hyponatremia - Diagnostic Evaluation Algorithm

Step 1: Consider whether Posm may actually be normal or elevated
Step 2:
Consider whether Posm ... Step 2: Check Uosm