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diagnosis management hemophagocytic hlh lymphohistiocytosis agglutinin anemia classification cold differential disease erythematosus hemeonc hemolytic lupus lymphoma myopathy myositis oncology prbc
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
of about three cases ... • History of EBV ... Immunosuppression • Autoimmune ... Lymphoma - Clinical ... classification #hematology
Major Clinical Trials and Evidence Summary for Transfusion Thresholds in Critical Care TRICC - NEJM 1999 -
NEJM 1999 - ICU FOCUS ... Blood saves lives ... unnecessary and cause ... /vmoitra) #EBM ... Transfusion #Thresholds #Hematology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
accumulation of clinical ... Assessment • Clinical ... Hemopathies+++: Hodgkin ... solid cancers • Autoimmune ... treatment #summary #rheumatology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
originate from a low-grade ... Viral infection, autoimmune ... Viral Infection Clinical ... - Mycoplasma, EBV ... hemolytic #anemia #hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... disease • Non-autoimmune ... rheumatologic diseases ... cyclophosphamide) • Hodgkin ... Erythematosus #Diagnosis #Rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Hypocomplementemia • Can cause ... salivary ducts Clinical ... Nephrogenic DI Hematologic ... Malignancy Risk: • Non-Hodgkins ... Sjogrens #Syndrome #Rheumatology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
RP-ILD), dermato-rheumatologic ... or ALS • Very slow ... • ANA < 20 % IBM ... statins - probably caused ... Myositis #Myopathy #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
hyperinflammatory syndrome caused ... Infections (e.g., EBV ... Clinical Presentation ... Low/absent NK-cell ... Diagnosis #Management #Hematology
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