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diagnosis algorithm treatment causes lfts nephrology transaminitis workup hyponatremia abnormal abscess aflp aih anesthesia anesthesiology ascites autoimmune biliary cancer chemistry
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury Hepatocellular Liver Injury • AST/ALT elevation
Liver Enzymes (LFTs ... value = (ALT + ULN ... phosphatase + ULN ... Transaminitis #diagnosis #differential ... #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... - Differential ... Severe ALT > 15x ULN ... Others #LFTs #Hepatology ... #LiverEnzymes #Differential
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
AST/ALT (5-10x ULN ... infiltration) Differential ... Intrahepatic Cholestasis Management ... #Pregnancy #hepatology ... obgyn #diagnosis #management
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Tests - Differential ... Severe - ALT >15X ULN ... Mild - ALT < 5x ULN ... Algorithm #diagnosis #hepatology
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Diagnosis and Management ... or symptoms of liver ... Idiosyncratic #differential ... #Diagnosis #Management ... gastroenterology #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Liver Chemistries ... R-value: Serum (ALT/ULN ... ALT) / (Alk phos/ULN ... chemistry #diagnosis #differential ... #Hepatology #transaminitis
Autoimmune Hepatitis Clinical Presentation - Highly variable clinical presentation, from subclinical disease to acute liver failure. -
disease to acute liver ... hepatocellular pattern of liver ... Hepatitis (eg Viral) Management ... AIH #Diagnosis #Management ... #Hepatology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Platelet Disorders - Differential ... : INR/PT, aPTT(liver ... (CVID, WAS), (neurologic ... bypass), LFT (liver ... Causes #Workup #hematology
Hepatitis B - Treatment Indications Treatment not indicated: • Immune tolerant state - HBe-Ag detectable, high HBV
IU/mL and ALT > ULN ... infection with severe liver ... mg/dL) or acute liver ... #Indications #management ... #hepatology
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
cholestasis → Cirrhosis/Liver ... • ALP > 1.5 x ULN ... or higher • Liver ... bile ducts Differential ... diagnosis #workup #hepatology
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