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rheumatology differential erythematosus systemic msk signs syndrome pain patterns antinuclear approach classification disease disorders druginduced monoarthritis monoarticular myopathy polyarthritis polyarticular
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
ANA Patterns and ... erythematosus (SLE ... Juvenile Idiopathic Arthritis ... #Antinuclear #Antibodies ... #rheumatology #diagnosis
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... Antibody refers to antibodies ... context of other symptoms ... #Antinuclear #Antibodies ... #rheumatology #diagnosis
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Differential Diagnosis ... : • Joint pain ... • Swan neck/Ulnar ... : • Symptoms limited
Joint Disorders - Differential Diagnosis Algorithm Monoarthritis • Septic • Crystalline - Gout
- Differential Diagnosis ... of Lumbar Spine and ... with Systemic Lupus ... Erythematosus (SLE ... should have other symptoms
Approach to Joint Pain - Diagnostic Framework 1) Chronicity 2) Inflammatory vs Non-Inflammatory 3) Number of Joints Involved 1) Chronicity:
Pain - Diagnostic ... spondyloarthropathies, lupus ... Chronic = RA, SLE ... #rheumatology # ... approach #workup
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Constitutional symptoms ... , Arthritis, myalgia ... • Immunologic Workup ... : - ANA > ... #diagnosis #management
Arthritis of the Hand - Arthritis Patterns Osteoarthritis: • Osteoarthritis of the hand usually involves the DIP and
MCP and PIP joints ... subluxation causing ulnar ... deviation • SLE ... patterns #hand #diagnosis ... #rheumatology #
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
• Arthritis domain ... in at least 2 joints ... Highly specific antibodies ... Classification #Criteria #SLE ... Erythematosus #diagnosis
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
: - Arthritis ... Auto-Antibodies ... : - ANA 95-100% ... and Lupus Mimickers ... autoantibodies #signs #symptoms
Rheumatoid arthritis (RA): Pathogenesis and Joint diseases features • RA affects 1% of population, women >
Rheumatoid arthritis ... characteristic antibodies ... Boutonniere's ulnar ... pathophysiology #signs #symptoms ... #diagnosis
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