12 results
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
Gitelman Syndrome ... alkalosis • Normal or low ... Hypocalciuria (spot urine ... ratio 0.5%) Differential ... #pathophysiology
Metabolic Alkalosis - Urinary Chloride Algorithm
Cl- responsive metabolic alkalosis
 • Kidney loss of Cl-
alkalosis • Normal/low ... , Gitelman syndrome ... Urine chloride is ... of sodium and potassium ... #nephrology #differential
Algorithm for patients with hypokalemia on the basis of the potassium-to-creatinine ratio in the urine
Urine K+
the basis of the potassium-to-creatinine ... Low-normal EABV ... , Gitelman syndrome ... #potassium #differential ... algorithm #diagnosis #nephrology
Hypokalemia - Differential Diagnosis Algorithm
Extra-renal Losses:
 • Normal Acid-Base: Low intake
 • Metabolic acidosis: Gl tract
Hypokalemia - Differential ... , Gitelman syndrom ... #Hypokalemia #Differential ... Algorithm #causes #potassium ... #low #nephrology
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting, NGT
Metabolic Alkalosis - Differential ... Urine Cl-: Vomiting ... (late) • High Urine ... , Gitelman Syndrome ... Diagnosis #Algorithm #nephrology
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted - 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting,
Metabolic Alkalosis - Differential ... Urine Cl-: Vomiting ... (late) • High Urine ... , Gitelman Syndrome ... Diagnosis #Algorithm #Nephrology
Causes of Metabolic Alkalosis: Differential Diagnosis
ECF volume contracted: urine chloride concentration <20 meq/L
 • Gastric alkalosis:
Metabolic Alkalosis: Differential ... furosemide-like lesion) • Gitelman ... other • Severe potassium ... Metabolic #Alkalosis #Differential ... Diagnosis #Causes #nephrology
Hypokalemia Evaluation Algorithm

Before evaluating hypokalemia, life threatening complications such as arrhythmias and paralysis should be looked
A urine K/Cr ratio ... , Gitelman syndrome ... diagnosis #Algorithm #differential ... #potassium #nephrology ... #low
Hypokalemia Differential Diagnosis Algorithm
Hypertensive:
 • High Al, Low R - Primary aldosteronism
 • High Al, High
Hypokalemia Differential ... , Gitelman's syndrome ... #Hypokalemia #Differential ... Diagnosis #Algorithm #nephrology ... #causes #low #potassium
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted - 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting,
Metabolic Alkalosis - Differential ... Urine Cl-: Vomiting ... (late) • High Urine ... , Gitelman Syndrome ... Diagnosis #Algorithm #Nephrology