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diagnosis management antinuclear classification differential erythematosus sle systemic table vasculitis activation amyloid amyloidosis antibodies autoantibodies autoinflammatory behcet behcets comparison cryoglobulinemia
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
likely it will be clinically ... Juvenile Idiopathic Arthritis ... SLE), Sjogren's Syndrome ... , Sjögren Syndrome ... #patterns #rheumatology
Behcet's Syndrome - Diagnosis Diagnostic Criteria for Behget's Syndrome (International Study Group for Behget's Disease): • Recurrent,
Behcet's Syndrome ... Abnormal pathergy test ... Most Common Clinical ... vasculitis) • Arthritis ... #criteria #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... findings (ANA, ... Non-autoimmune rheumatologic ... Clinical Features ... pain • Swan neck/Ulnar
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
• Systemic lupus ... SJIA], systemic lupus ... Liver function tests ... Histopathologic criteria ... #Rheumatology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
association • M > F Clinical ... (Clinical Dx). ... Positive pathergy test ... is a skin prick test ... signs #symptoms #rheumatology
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... Studies in Rheumatic Diseases ... joint • Systemic lupus ... and RF (if clinical ... diagnosis #testing #Rheumatology
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Association with disease ... -15% If SLE is clinically ... suspected, tests ... SLE-SSc-AlM overlap syndromes ... erythematosus #diagnosis #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
to 1:1 F:M • Clinical ... Constitutional symptoms, Arthritis ... 40, F:M 9:1 • Clinical ... Evolution: Chronic disease ... comparison #table #rheumatology
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome Clinical Syndrome: • Common Clinical Features: alveolitis, ear and
Clinical Syndrome ... thromboembolic disease ... (MDS) Most met criteria ... • giant cell arteritis ... Autoinflammatory #Somatic #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Others: • Lupus ... such as systemic lupus ... retinopathy Lab Tests ... LFT • ESR • ANA ... differential #diagnosis #rheumatology
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