13 results
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings
• Primary Sjögren's is a solitary process whereas secondary Sjögren's
accompanies other autoimmune ... like rheumatoid arthritis ... (RA) or systemic ... erythematosus (SLE ... ) Signs / Symptoms
Joint Disorders - Differential Diagnosis Algorithm
Monoarthritis
 • Septic
 • Crystalline
     - Gout
- (Reiter’s syndrome ... (RA) - Inflammation ... autoimmune disease ... Erythematosus (SLE ... should have other symptoms
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Positive ANA ≠ Autoimmune ... context of other symptoms ... ), Sjogren's Syndrome ... , Sjögren Syndrome ... ANA #patterns #rheumatology
Pseudogout Summary - Calcium Pyrophosphate Deposition Disease (CPPD)

Pathophysiology:
Pyrophosphate produced by chondrocytes likely precipitates with calcium to
joints (shoulders, wrists ... • Resembles RA ... • Systemic glucocorticoids ... Crowned Dens Syndrome ... Deposition #Disease #Rheumatology
Rheumatoid arthritis (RA): Pathogenesis and Joint diseases features
 • RA affects 1% of population, women >
Rheumatoid arthritis ... boggy" joints, esp carpal ... Boutonniere's ulnar ... deviation, etc • Systemic ... pathophysiology #signs #symptoms
Autoimmune Myositis
Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
weakness, less systemic ... symptoms, and less ... anti-synthetase syndrome ... myositis, and arthritis ... Myositis #diagnosis #rheumatology
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
Systemic disease ... meningitis), MCC CNS symptoms ... Oral aphthae : SLE ... : SLE, Reactive ... #rheumatology #
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
activate the immune system ... diseases: - 10% SLE ... or RA - 5 to ... erythematosus (SLE ... classification #rheumatology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... disease • Non-autoimmune ... rheumatologic diseases ... pain • Swan neck/Ulnar ... Induced Lupus: • Symptoms
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
be any age) Autoimmune ... overlaps with RA ... , SLE • Mikulicz ... Arthralgia and Arthritis ... #Rheumatology #