27 results
Hypernatremia - Differential Diagnosis Workup Algorithm

1) Check Urine Osmolality:
 > 600 mOsm/kg - Implies extrarenal mechanism
Diagnosis Workup Algorithm ... 1) Check Urine ... mechanism 2) Volume ... • Euvolemic (Low ... #nephrology #sodium
True Hyponatremia Differential Algorithm

Instead (or in addition) of volume status examination, check urine sodium and serum
Differential Algorithm ... in addition) of volume ... low, uric acid ... and uric acid low ... #Diagnosis #Nephrology
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting, NGT
Volume Depleted ... , Gitelman Syndrome ... Volume Expanded ... 1° / 2° hyperaldosteronism ... #nephrology
Hypernatremia Diagnosis and Workup

Step 1 . Repeat the sodium concentration.
Step 2.  Check plasma osmolality.
NORMAL PLASMA
Workup Step 1 ... Repeat the sodium ... • nephrotic syndrome ... Diagnosis #Workup #Algorithm ... #Nephrology
Volume Based Approach to Hyponatremia
Hypovolemic, Serum uric acid >4
 • Urine Na <20: Extra-renal losses
 •
Volume Based Approach ... to Hyponatremia ... Cirrhosis, Nephrotic syndrome ... algorithm #diagnosis ... #sodium #low #nephrology
Gitelman Syndrome Pathophysiology
Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Gitelman Syndrome ... Gitelman Syndrome ... prevalence of 1- ... alkalosis - Volume ... #Syndrome #Pathophysiology
Hyponatremia Differential Diagnosis Algorithm - Utilizing Uric Acid 
ADH promotes Urea/uric acid excretion along with water
Hyponatremia Differential ... Diagnosis Algorithm ... ADH promotes Urea ... water retention 1) ... #nephrology #sodium
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted - 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting,
Volume Depleted ... , Gitelman Syndrome ... Volume Expanded ... - 1° or 2° hyperaldosteronism ... #Nephrology #Causes
Physiologic Approach to Hypotonic Hyponatremia
The next time you have a case of hypotonic hyponatremia, give the
algorithm Urine ... +K / serum Na >1 ... can be high or low ... Cirrhosis, Nephrotic syndrome ... #nephrology
Cerebral Salt Wasting vs SIADH - Pathophysiology 
1) Neurological event
2) Sodium loss from tubules
3) Naturiesis →
1) Neurological ... event 2) Sodium ... → Subclinical volume ... #diagnosis #nephrology ... #hyponatremia #