42 results
Gitelman Syndrome Pathophysiology
Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Gitelman Syndrome ... Gitelman Syndrome ... thiazide-sensitive sodium-chloride ... #Syndrome #Pathophysiology ... #nephrology #diagnosis
Hypernatremia Differential Diagnosis Algorithm - Diabetes Insipidus Workup

Step #1 - Consider the history
Step #2 - Assess
Hypernatremia Differential Diagnosis ... Insipidus Workup ... history Step #2 ... Uglucose Step #3 ... #Sodium #nephrology
Hyponatremia Differential Diagnosis Algorithm - Utilizing Uric Acid 
ADH promotes Urea/uric acid excretion along with water
ADH promotes Urea ... Serum Osmolarity 2) ... Urine Osmolarity 3) ... Urine Sodium 4) ... #Algorithm #nephrology
Hypernatremia Diagnosis and Workup

Step 1 . Repeat the sodium concentration.
Step 2.  Check plasma osmolality.
NORMAL PLASMA
Repeat the sodium ... Step 2. ... administration Step 3. ... #Workup #Algorithm ... #Nephrology
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting, NGT
- Differential Diagnosis ... Algorithm Volume ... , Gitelman Syndrome ... Expanded 1° / 2° ... #Algorithm #nephrology
Hypernatremia - Differential Diagnosis Workup Algorithm

1) Check Urine Osmolality:
 > 600 mOsm/kg - Implies extrarenal mechanism
- Differential Diagnosis ... Workup Algorithm ... renal mechanism 2) ... #Workup #Algorithm ... #nephrology #sodium
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted - 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting,
- Differential Diagnosis ... Algorithm Volume ... , Gitelman Syndrome ... Expanded - 1° or 2° ... #Algorithm #Nephrology
Inherited Defects in Kidney Tubule Epithelial Cells

Renal glucosuria - Na+-dependent glucose cotransporter
Cystinuria - Amino acid transporter
Bartter
ascending limb Gitelman ... cell epithelial sodium ... of epithelial sodium ... Defects #Kidney #Nephrology ... #Diagnosis #Differential
Hypernatremia - Diagnostic Evaluation Algorithm
Step 1: Consider history. Most patients presenting with hypernatremia are either very
Evaluation Algorithm ... Step 2: Check Uosm ... Step 3: If patient ... #Workup #Evaluation ... #Algorithm #Sodium
Cerebral Salt Wasting vs SIADH - Pathophysiology 
1) Neurological event
2) Sodium loss from tubules
3) Naturiesis →
Wasting vs SIADH - Pathophysiology ... Neurological event 2) ... Sodium loss from ... tubules 3) Naturiesis ... #diagnosis #nephrology