21 results
Localization of Renal Tubular Defects
Fanconi Syndrome: Proximal tubule
Bartter Syndrome: Thick ascending loop of Henle
Gitelman Syndrome: Distal
Localization of Renal ... tubule #Liddle ... #Bartter #Gitelman ... Nephron #Defects #Pathophysiology ... #Nephrology
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting, NGT
Cl-: Diuretics, Bartter ... Syndrome, Gitelman ... hyperaldosteronism • High PRA: Renal ... , Liddle syndrome ... #nephrology
Hypokalemia - Differential Diagnosis Algorithm
Extra-renal Losses:
 • Normal Acid-Base: Low intake
 • Metabolic acidosis: Gl tract
Extra-renal Losses ... Low Aldosterone: Liddle's ... thiazide diuretics, Bartter ... syndrome, Gitelman ... potassium #low #nephrology
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted - 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting,
Cl-: Diuretics, Bartter ... Syndrome, Gitelman ... hyperaldosteronism • High PRA: Renal ... , Liddle syndrome ... #Nephrology #Causes
Inherited Defects in Kidney Tubule Epithelial Cells

Renal glucosuria - Na+-dependent glucose cotransporter
Cystinuria - Amino acid transporter
Bartter
Epithelial Cells Renal ... acid transporter Bartter ... ascending limb Gitelman ... convoluted tubule Liddle ... Defects #Kidney #Nephrology
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
Gitelman Syndrome ... • Bartter syndrome ... • Pseudo Bartter-Gitelman ... #nephrology #management ... #pathophysiology
Causes of Hypokalemia - Differential Diagnosis Algorithm
Defining the cause of hypokalemia starts by measuring urinary K
hypokalemia • Renal ... • Diuretics, Bartter's ... syndrome, Gitelman's ... glycyrrhizic acid, Liddle's ... #causes #nephrology
Hypernatremia - Differential Diagnosis Workup Algorithm

1) Check Urine Osmolality:
 > 600 mOsm/kg - Implies extrarenal mechanism
Differential Diagnosis Workup ... Algorithm 1) ... mOsm/kg - Implies renal ... #Algorithm #nephrology ... #sodium
Hypernatremia Diagnosis and Workup

Step 1 . Repeat the sodium concentration.
Step 2.  Check plasma osmolality.
NORMAL PLASMA
Diagnosis and Workup ... Repeat the sodium ... • nephrotic syndrome ... Hypernatremia #Diagnosis #Workup ... #Algorithm #Nephrology
Hypokalemia Evaluation Algorithm

Before evaluating hypokalemia, life threatening complications such as arrhythmias and paralysis should be looked
suggests extra-renal ... mineralocorticoid excess, Liddle's ... Emesis, Diuretics, Bartter ... syndrome, Gitelman ... differential #potassium #nephrology