17 results
Localization of Renal Tubular Defects
Fanconi Syndrome: Proximal tubule
Bartter Syndrome: Thick ascending loop of Henle
Gitelman Syndrome: Distal
loop of Henle Gitelman ... Syndrome: Distal ... Fanconi #Bartter #Gitelman ... Nephron #Defects #Pathophysiology ... #Nephrology
Gitelman Syndrome Pathophysiology
Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Gitelman Syndrome ... Pathophysiology ... Gitelman Syndrome ... #Syndrome #Pathophysiology ... #nephrology #diagnosis
Algorithm showing a stepwise approach to the assessment and investigation of a possible neuropathy. CIDP, chronic
electromyography; GBS ... , Guillain-Barré ... syndrome; HNPP, ... #Diagnosis #Neurology
Guillain-Barré Syndrome (GBS)
Acute autoimmune demyelinating polyradiculoneuropathy that presents with rapidly progressive flaccid weakness
Epidemiology:
 • Incidence: 1
Guillain-Barré Syndrome ... the underlying pathophysiology ... #Guillain #Barre ... #Syndrome #diagnosis ... #management #neurology
Guillain-Barre Syndrome - Summary

Acute AIDP that presents with rapidly progressive flaccid weakness

Epidemiology:
 • 1-2 cases/100,000 per
Guillain-Barre Syndrome ... Pathophysiology ... Miller Fisher Syndrome ... #Syndrome #diagnosis ... management #treatment #neurology
Guillain–Barré syndrome (GBS)
(aka: Landry–Guillain–Barré–Strohl syndrome:
	Most common cause of acute flaccid paralysis
	Rapidly progressive ascending paralysis & areflexia
	Autonomic
Guillain–Barré syndrome ... (GBS) (aka: Landry–Guillain–Barré–Strohl ... syndrome:  Most ... lower to upper areas ... compylobacterjejuni #GBS
Reflex Testing - Causes of Hyporeflexia and Hyperreflexia
Focal Hyporeflexia: 
 • Radiculopathy, Mononeuropathy, Polyneuropathy, Acute stroke,
Guillain-Barré syndrome ... Hyperthyroidism, Serotonin syndrome ... differential #diagnosis #table ... #neurology
Inherited Defects in Kidney Tubule Epithelial Cells

Renal glucosuria - Na+-dependent glucose cotransporter
Cystinuria - Amino acid transporter
Bartter
transporter Bartter syndrome ... ascending limb Gitelman ... tubule Liddle syndrome ... Defects #Kidney #Nephrology ... #Differential #Table
Hypochloremia - Differential Diagnosis Algorithm

Cause - Decreased Intake:
 • Low salt in diet
 • Exclusive D5W
- Bartter - Gitelman ... decarboxylation/gas ... muscle cells • Gas ... Diagnosis #Algorithm #Pathophysiology ... #Nephrology #Chloride
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
Gitelman Syndrome ... cotransporter • Gitelman's ... Pseudo Bartter-Gitelman ... #nephrology #management ... #pathophysiology