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diagnosis differential gitelman alkalosis hypokalemia metabolic aids associated causes dementia disorder epithelial fanconi hand hiv hypochloremia inherited kidney liddle localization
Algorithm for Differentiating Gitelman syndrome from Bartter syndrome • Urine Chloride • Urine Ca/Cr ratio Dr. Krithika
Algorithm for Differentiating ... from Bartter syndrome ... • Urine Chloride ... #Bartter #Algorithm ... #nephrology #hypokalemia
Localization of Renal Tubular Defects Fanconi Syndrome: Proximal tubule Bartter Syndrome: Thick ascending loop of Henle Gitelman Syndrome: Distal
Renal Tubular Defects ... Proximal tubule Bartter ... #Fanconi #Bartter ... #Pathophysiology ... #Nephrology
Metabolic Alkalosis - Urinary Chloride Algorithm Cl- responsive metabolic alkalosis • Kidney loss of Cl-
Algorithm Cl- ... diuretic use, Bartter ... syndrome, Gitelman ... #urine #Algorithm ... #nephrology #differential
Causes of Metabolic Alkalosis: Differential Diagnosis ECF volume contracted: urine chloride concentration <20 meq/L • Gastric alkalosis:
contracted: urine chloride ... expanded: urine chloride ... tubule reabsorptive defect ... actively working • Bartter ... Diagnosis #Causes #nephrology
Inherited Defects in Kidney Tubule Epithelial Cells Renal glucosuria - Na+-dependent glucose cotransporter Cystinuria - Amino acid transporter Bartter
Inherited Defects ... acid transporter Bartter ... Epithelial #Inherited #Defects ... #Kidney #Nephrology ... #Differential #Table
Hypochloremia - Differential Diagnosis Algorithm Cause - Decreased Intake: • Low salt in diet • Exclusive D5W
Differential Diagnosis Algorithm ... - Diuresis - Bartter ... • Fatigue Chloride ... #Pathophysiology ... #Nephrology #Chloride
HIV-Associated Neurocognitive Disorder (HAND) Definition: HIV-Associated Neurocognitive disorders categories: • Asymptomatic neurocognitive impairment • Mild neurocognitive impairment • HIV dementia Pathophysiology: HIV frequently
HIV dementia Pathophysiology ... the blood-brain barrier ... (BBB), and infects ... the blood-brain barrier ... The clinical syndrome
Gitelman Syndrome Overview What? • Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter • Gitelman's syndrome
• Bartter syndrome ... • Pseudo Bartter-Gitelman ... • Congenital chloride ... #diagnosis #nephrology ... #management #pathophysiology
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