10 results
Localization of Renal Tubular Defects
Fanconi Syndrome: Proximal tubule
Bartter Syndrome: Thick ascending loop of Henle
Gitelman Syndrome: Distal
Defects Fanconi ... tubule Bartter ... #Fanconi #Bartter ... #Pathophysiology ... #Nephrology
Inherited Defects in Kidney Tubule Epithelial Cells

Renal glucosuria - Na+-dependent glucose cotransporter
Cystinuria - Amino acid transporter
Bartter
Inherited Defects ... acid transporter Bartter ... ascending limb Gitelman ... #Kidney #Nephrology ... #Differential #Table
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
Gitelman Syndrome ... • Bartter syndrome ... • Pseudo Bartter-Gitelman ... #nephrology #management ... #pathophysiology
Causes of Hypokalemia - Differential Diagnosis Algorithm
Defining the cause of hypokalemia starts by measuring urinary K
Differential Diagnosis Algorithm ... hypokalemia • Renal tubular ... • Diuretics, Bartter's ... syndrome, Gitelman's ... #causes #nephrology
Gerstmann Syndrome
1) Finger agnosia - Inability to name their own fingers, affecting both sides
2) Right-left confusion
Gerstmann Syndrome ... Agraphia (without alexia ... patient is still able ... subjacent white matter ... #neurology #diagnosis
Causes of Metabolic Alkalosis: Differential Diagnosis
ECF volume contracted: urine chloride concentration <20 meq/L
 • Gastric alkalosis:
diuretics after renal tubule ... reabsorptive defect ... actively working • Bartter ... furosemide-like lesion) • Gitelman ... Diagnosis #Causes #nephrology
Hypochloremia - Differential Diagnosis Algorithm

Cause - Decreased Intake:
 • Low salt in diet
 • Exclusive D5W
- Diuresis - Bartter ... - Gitelman ... filtration rate by tubulo-glomerular ... #Pathophysiology ... #Nephrology #Chloride
Metabolic Alkalosis - Urinary Chloride Algorithm
Cl- responsive metabolic alkalosis
 • Kidney loss of Cl-
Urinary Chloride Algorithm ... diuretic use, Bartter ... syndrome, Gitelman ... syndrome, Hypomagnesemia ... #nephrology #differential
HIV-Associated Neurocognitive Disorder (HAND)

Definition:
HIV-Associated Neurocognitive disorders categories:
• Asymptomatic neurocognitive impairment
• Mild neurocognitive impairment
• HIV dementia

Pathophysiology:
HIV frequently
HIV dementia Pathophysiology ... (BBB), and infects ... volume • Patchy areas ... The clinical syndrome ... motor slowing and ataxia
Causes of Hypokalemia
Transcellular Shifts:
 - Alkalosis, Increased plasma insulin (treatment of diabetic ketoacidosis), ß-Adrenergic agonists, Hypokalemic
tobacco, Renal tubular ... Osmotic diuresis, Bartter's ... diuretic use), Gitelman's ... megaloblastic anemia ... differential #diagnosis #nephrology