15 results
Localization of Renal Tubular Defects
Fanconi Syndrome: Proximal tubule
Bartter Syndrome: Thick ascending loop of Henle
Gitelman Syndrome: Distal
Defects Fanconi ... loop of Henle Gitelman ... Fanconi #Bartter #Gitelman ... #Pathophysiology ... #Nephrology
Inherited Defects in Kidney Tubule Epithelial Cells

Renal glucosuria - Na+-dependent glucose cotransporter
Cystinuria - Amino acid transporter
Bartter
Inherited Defects ... ascending limb Gitelman ... Increased open time and ... #Kidney #Nephrology ... #Differential #Table
Hypokalemia - Differential Diagnosis Algorithm
Extra-renal Losses:
 • Normal Acid-Base: Low intake
 • Metabolic acidosis: Gl tract
Differential Diagnosis Algorithm ... , Gitelman syndrom ... Differential #Diagnosis #Algorithm ... #causes #potassium ... #low #nephrology
Gitelman Syndrome Pathophysiology
Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Gitelman Syndrome ... Gitelman Syndrome ... in the distal tubule ... #Syndrome #Pathophysiology ... #nephrology #diagnosis
Hypomagnesemia - Etiologies by Mechanism

Decreased GI Uptake 
 - Poor dietary intake (particularly common in alcoholics)
Medications - Loop and ... Transient renal tubular ... - Gitelman ... Genetic defects ... Low #Magnesium #Table
Causes of Hypokalemia - Differential Diagnosis Algorithm
Defining the cause of hypokalemia starts by measuring urinary K
• Skin and/or ... hypokalemia • Renal tubular ... , Gitelman's syndrome ... #causes #nephrology ... #potassium
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
Gitelman Syndrome ... distal convoluted tubule ... , Renal tubular ... #nephrology #management ... #pathophysiology
Hypokalemia Evaluation Algorithm

Before evaluating hypokalemia, life threatening complications such as arrhythmias and paralysis should be looked
Hypokalemia Evaluation Algorithm ... as arrhythmias and ... treated with IV potassium ... , Gitelman syndrome ... #nephrology #low
Causes of Metabolic Alkalosis: Differential Diagnosis
ECF volume contracted: urine chloride concentration <20 meq/L
 • Gastric alkalosis:
diuretics after renal tubule ... reabsorptive defect ... furosemide-like lesion) • Gitelman ... other • Severe potassium ... Diagnosis #Causes #nephrology
Metabolic Alkalosis - Urinary Chloride Algorithm
Cl- responsive metabolic alkalosis
 • Kidney loss of Cl-
Urinary Chloride Algorithm ... diuretic use, Bartter syndrome ... , Gitelman syndrome ... potassium acid ... #nephrology #differential