23 results
Gitelman Syndrome - Diagnosis and Workup
Blood Work:
 - Hypokalemia
 - Hypomagnesemia
 - Metabolic Alkalosis
 - Elevated
Gitelman Syndrome ... Elevated Renin Urine ... dr_missyhanna #Gitelman ... #Syndrome #Diagnosis ... #Workup #nephrology
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting, NGT
Urine Cl-: Vomiting ... , NGT suction, Low ... (late) • High Urine ... , Gitelman Syndrome ... Diagnosis #Algorithm #nephrology
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted - 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting,
Urine Cl-: Vomiting ... , NGT suction, Low ... (late) • High Urine ... , Gitelman Syndrome ... Diagnosis #Algorithm #Nephrology
Pathophysiology of Tumor Lysis Syndrome (TLS)
Tumor Cell Lysis
-> Release of DNA
 • Purines -> Hypoxanthine /
Pathophysiology ... of Tumor Lysis Syndrome ... -> Uric Acid (low ... Precipitation => • Urate ... Nephropathy (low
Algorithm for patients with hypokalemia on the basis of the potassium-to-creatinine ratio in the urine
Urine K+
Low-normal EABV ... , Low Plasma HCO3 ... Plasma HCO3- • Low ... , Gitelman syndrome ... algorithm #diagnosis #nephrology
Hypokalemia Evaluation Algorithm

Before evaluating hypokalemia, life threatening complications such as arrhythmias and paralysis should be looked
A urine K/Cr ratio ... • Diarrhea A urine ... , Gitelman syndrome ... differential #potassium #nephrology ... #low
Hyponatremia Differential Diagnosis Algorithm - Utilizing Uric Acid 
ADH promotes Urea/uric acid excretion along with water
ADH promotes Urea ... Osmolarity 2) Urine ... Uric Acid - Low ... Acid → renal salt wasting ... Diagnosis #Algorithm #nephrology
Hypomagnesemia - Etiologies by Mechanism

Decreased GI Uptake 
 - Poor dietary intake (particularly common in alcoholics)
Familial renal Mg wasting ... syndromes ... - Gitelman syndrome ... Differential #Diagnosis #Low ... Classification #Causes #Workup
Volume Based Approach to Hyponatremia
Hypovolemic, Serum uric acid >4
 • Urine Na <20: Extra-renal losses
 •
Cerebral salt wasting ... Hypothyroidism, Low ... Cirrhosis, Nephrotic syndrome ... diagnosis #sodium #low ... #nephrology
Workup for Hypophosphatemia - Differential Diagnosis Framework
Rule out spurious hypophosphatemia: paraproteinemia, acute leukemia
Measure Urine Fractional Excretion
Workup for Hypophosphatemia ... leukemia Measure Urine ... • Normal or Low ... - Normal or Low ... #phosphate #nephrology