28 results
Paths to Defective Homologous Recombination DNA Repair in Breast Cancer. Each individual mutation or epigenetic aberration
DNA Repair in Breast ... common feature of breast ... cancer #Pathophys #Honc ... BreastCancer #DNARepair #NEJM
The diagonal crease in the lobe of the ear (Frank's sign) is a sign theoretically related
The diagonal crease ... the lobe of the ear ... (Frank's sign) ... is a sign theoretically ... Earlobe #Clinical #Photo
Summary table of common benign breast diseases and how to manage them. 
Fibroadenoma:
 • Most common
common benign breast ... benign tumour of breast ... e.g. biopsy, car ... bruising/erythema/sign ... of trauma Breast
Lymphangitis on the Abdomen - Examination revealed a warm, indurated plaque with extension toward her left
toward her left breast ... A 43-year-old man ... Lymphangitis #Abdominal #NEJM
Radiation-Induced Angiosarcoma after Breast-Cancer Treatment - Physical examination revealed an area of skin 10 cm in
Angiosarcoma after Breast-Cancer ... the dermis and breast ... Clinical #Derm #Honc ... #Angiosarcoma #Breast ... Radiation #Microscopy #NEJM
Mastoiditis: Pathogenesis and clinical findings

Acute or Chronic Otitis Media -> 
Stage 1: Hyperemeia of the mastoid
inflammation of middle ear ... cavity as middle ear ... into contiguous areas ... postauricular crease ... pathophysiology #signs
The patient was noted to have bilateral Frank's sign, which is a diagonal crease in the
bilateral Frank's sign ... is a diagonal crease ... lobule to the rear ... #Photo #PhysicalExam ... #Ear #Clinical
Common Dermatological Conditions - Distribution and Morphology
 • Acne vulgaris - Face, upper back, chest -
eyebrows, perinasal areas ... Erythema with greasy ... associated with signs ... - Sun-exposed areas ... with adherent, greasy
Giant cell arteritis (GCA)

Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
systemic sx + signs ... ESR usually at least ... in literature (NEJM ... cases (Cornelia NEJM ... GCA #Temporal #Signs
Adhesive Capsulitis (Frozen Shoulder) - Pathogenesis and Clinical Findings

 • Primary (Idiopathic): Unknown etiology, but associated
, rotator cuff tear ... recovery after breast ... will eventually break ... diagnosis #symptoms #signs