115 results
Role of Uric Acid in the Inflammation of Gout

Allopurinol, Febuxostat - Xanthine oxidase
Colchicine - Release of
Role of Uric Acid ... Inflammation of Gout ... inflammation #gout ... pathophysiology #pharmacology
Algorithm for the Treatment of Uremic Pruritus
Nonpharmacologic Treatments:
 • Daily topical emollient
 • Avoidance of extremes
the Treatment of Uremic ... Evidence-Based Off-Label Pharmacologic ... Treatments of Uremic ... 2.5 mcg/d) #Uremic ... #Pruritus #uremia
Uric Acid Homeostasis
In the liver, purines are metabolized to uric acid. The last step in purine
Uric Acid Homeostasis ... metabolized to uric ... The gout drug pegloticase ... #Homeostasis #Gout ... Pathophysiology #Pharmacology
Gout: Pathogenesis and Clinical Findings
 - Conditions of rapid cell turnover: hemolysis, psoriasis, lymphoproliferative disorders
 -
Gout: Pathogenesis ... , excretion of uric ... into joints -> Uric ... Chronic tophaceous gout ... Complications #Gout
Diuretic Electrolyte Excretion Effects 
Diuresis, Na+, K+, Mg2+, Ca2+, Cl-, HCO3-, Uric Acid
 - Thiazide Type
+, Cl-, HCO3-, Uric ... electrolytes #effects #pharmacology
Highland EM Ultrasound - Ultrasound Guided ED Pain Management
#Pharmacology #Local #Regional #Anesthesia #Anesthetics #DosingGuide #MaxDose #Toxicity
Highland EM Ultrasound ... - Ultrasound Guided ... Pain Management #Pharmacology
TACROLIMUS - Side Effects Mnemonic

Tremor 
Alopecia 
Cardiovascular (HTN) 
Renal insufficiency 
Oncologic (Skin Cancer) 
Lipids (hyperlipidemia) 
Insulin
Magnesium wasting Uric ... Seizures #Pharmacology
Oral Antihypertensive Medications - Selection by Comorbidities
Comorbidities: 
 • Stable Angina, HFpEF, HFrEF, AFib, TAA/Marfan, Aortic
Osteoporosis, Gout ... Comorbidities #pharmacology
Causes of Hyperuricemia
Increased production
 • Solid-organ transplant
 • Tumor lysis syndrome
 • Rhabdomyolysis
 • Lesch Nyhan
lactic acid + uric ... degradation -> uric ... -> purines -> uric ... of purines to uric ... #differential #gout
Hyperuricemia: Pathogenesis and Complications

 - Hypercalcemia (due to diseases like Sarcoidosis and Hyperparathyroidism) -> Accumulation of
kidneys to filter uric ... Decr secretion of uric ... Under-excretion of Uric ... abnormally high uric ... Complications #Gout