26 results
diagnosis differential management algorithm anemia hemophagocytic hlh lymphohistiocytosis disorders hemeonc hemolysis hemolytic hivaids intravascular leukemia mds myelodysplastic opportunistic pharmacology prevention
Causes of Neutropenia with Pancytopenia - Differential Diagnosis Algorithm Sequestration: • Splenomegaly Marrow Infiltration: • Hematologic and non-hematologic
Causes of Neutropenia ... malignancies • Infection ... • Primary Myelofibrosis ... Stem cell damage ... #Hematology
Hemolysis - Diagnostic Algorithm and Causes Increased red cell production: • Increased Reticulocytosis/polychromasia • Erythroid
Algorithm and Causes ... Increased red cell ... Increased red cell ... Urobilinogen • + urinary ... #Workup #Hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Causes of Thrombocytosis ... Myelogenous Leukemia • Primary ... Myelofibrosis Infectious ... effect following treatment ... #Hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
= funny-shaped cells ... old, ~10,000 new cases ... risk-stratification • Risks: infection ... Allogeneic stem cell ... #hematology #oncology
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
evaluation or workup ... /µL Workup • Screen ... for secondary causes ... glucocorticoid treatment ... Differential #diagnosis #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
weeks without infection ... or basket cells ... microglobulin Treatment ... Leukemia #diagnosis #workup ... #oncology #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... usually IgM) (e.g. primary ... Hemoglobinopathies (e.g. sickle cell ... Extravascular #Causes ... differential #diagnosis #hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Diagnosis and Workup ... procedures - Infection ... unclear, or if a primary ... hematologic disorder ... #Workup #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
assessment+++ Primary ... Drugs, Unknown cause ... Treatment: • ... diagnosis #management #treatment ... #summary #rheumatology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Malaise, bleeding, infections ... -> AML: Blast crises ... + distinctive primary ... #Leukemia #Hematology ... #Oncology #Diagnosis
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