81 results
Pathophysiology of Tumor Lysis Syndrome (TLS)
Tumor Cell Lysis
-> Release of DNA
 • Purines -> Hypoxanthine /
of Tumor Lysis Syndrome ... (TLS) Tumor Cell ... #TumorLysis #Syndrome ... #TLS #Pathophysiology ... #UricAcid
Classification of Tumor Lysis Syndrome (TLS) and Treatment of Metabolic Abnormalities of TLS
Laboratory TLS:
 • Uric
of Tumor Lysis Syndrome ... (TLS) and Treatment ... Laboratory TLS ... #TumorLysis #Syndrome ... #management #oncology
Reflex Testing - Causes of Hyporeflexia and Hyperreflexia
Focal Hyporeflexia: 
 • Radiculopathy, Mononeuropathy, Polyneuropathy, Acute stroke,
Reflex Testing - Causes ... Deep coma (any cause ... Guillain-Barré syndrome ... injury, Early ALS ... Hyperthyroidism, Serotonin syndrome
Tumor Lysis Syndrome
An acute, life-threatening condition that appears within 7 days of starting cytotoxic therapies in
Tumor Lysis Syndrome ... #Tumor #Lysis #Syndrome ... #TLS #oncology ... #management #UricAcid
Inherited Colorectal Cancer (CRS) Syndromes
Adenomatous Polyposis Syndromes:
 • Familial Adenomatous Polyposis (FAP), Attenuated FAP (AFAP), MUTYH
Colorectal Cancer (CRS) Syndromes ... Adenomatous Polyposis Syndromes ... Urinary → Lynch Syndrome ... Tuberous Sclerosis (TS ... #diagnosis #management
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
vs Tumor Lysis Syndrome ... high WBC count cause ... leukapheresis - TLS ... #TLS #diagnosis ... #management #hematology
Tumor Lysis Syndrome - Workup and Management

Initial workup: BMP, Serum uric acid, LDH, Urine output, Consider
Tumor Lysis Syndrome ... - Workup and Management ... Treatment of Clinical TLS ... MatthewHoMD #TLS ... #Tumor #Lysis #Syndrome
“H’s & T’s“ - The reversible causes of Cardiac Arrest 
Hypovolemia, Hypoxia/Hypoxemia, Hydrogen Ion Excess (Acidosis),
“H’s & T’s“ - The ... reversible causes ... diagnosis #arrest #management
Dyspnea - Differential Diagnosis Framework

Cardiovascular Causes of Dyspnea:
 • Myocardium:
	- Heart failure
	- CAD/ACS
	- Valvulopathy
 • Electrical:
	-
Cardiovascular Causes ... Tamponade Pulmonary Causes ... Hepatopulmonary syndrome ... Other Causes ... Guillain Barre - ALS
Causes of Hyperuricemia
Increased production
 • Solid-organ transplant
 • Tumor lysis syndrome
 • Rhabdomyolysis
 • Lesch Nyhan
Causes of Hyperuricemia ... • Tumor lysis syndrome ... • Lesch Nyhan syndrome ... Hyperuricemia #Causes ... #UricAcid #diagnosis