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diagnosis management differential neurology oncology algorithm tumor nephrology pediatrics rhabdomyolysis tumorlysis barre behcets cancer cauda caudaequina diarrhea disease emergencies encephalopathy
Pathophysiology of Tumor Lysis Syndrome (TLS) Tumor Cell Lysis -> Release of DNA • Purines -> Hypoxanthine /
Pathophysiology of Tumor Lysis ... Syndrome (TLS) ... Tumor Cell Lysis ... #TLS #Pathophysiology ... #UricAcid
Classification of Tumor Lysis Syndrome (TLS) and Treatment of Metabolic Abnormalities of TLS Laboratory TLS: • Uric
Classification of Tumor Lysis ... Syndrome (TLS) ... and Treatment of ... hypocalcemia Treatment ... #TumorLysis #Syndrome
Tumor Lysis Syndrome An acute, life-threatening condition that appears within 7 days of starting cytotoxic therapies in
Tumor Lysis Syndrome ... malignancies Treatments ... wandering_er #Tumor #Lysis ... #Syndrome #TLS ... oncology #management #UricAcid
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
high WBC count cause ... organ damage • Treatment ... leukapheresis - TLS ... Low calcium • Treatment ... #Syndrome #TLS
Tumor Lysis Syndrome - Workup and Management Initial workup: BMP, Serum uric acid, LDH, Urine output, Consider
Tumor Lysis Syndrome ... of the above Treatment ... of Clinical TLS ... MatthewHoMD #TLS ... Syndrome #diagnosis
Causes of Pediatric Diarrhea - Differential Diagnosis Algorithm Infectious: • Viral • Bacterial • Parasitic Malabsorption: • Lactase
Causes of Pediatric ... Toddler's Diarrhea • Constipation ... • Short Bowel Syndrome ... Irritable Bowel Syndrome ... #Peds #Pediatrics
Causes of Pediatric Constipation - Differential Diagnosis Algorithm Dietary / Functional: • Insufficient Volume / Bulk Neurologic: •
Causes of Pediatric ... Constipation - ... Guillain-Barré Syndrome ... Diagnosis #Algorithm #Causes ... #Peds #Pediatrics
Causes of Hyperuricemia Increased production • Solid-organ transplant • Tumor lysis syndrome • Rhabdomyolysis • Lesch Nyhan
Causes of Hyperuricemia ... transplant • Tumor lysis ... syndrome • Rhabdomyolysis ... • Lesch Nyhan syndrome ... #UricAcid #diagnosis
Oncologic Emergencies - Differential Diagnosis Framework HEMATOLOGIC ONCOLOGIC EMERGENCIES: Hyperviscosity Syndrome: • Spontaneous bleeding • Shortness of breath
Hyperviscosity Syndrome ... EMERGENCIES: Tumor Lysis ... Syndrome: • Azotemia ... • Thirst • Constipation ... , vomiting • Constipation
Causes of Neuromuscular Weakness • Spinal Cord: Demyelinating Disease (MS), Epidural abscess, Infarction, Syringomyelia, Tetanus, Transverse
Causes of Neuromuscular ... Motor Nerves: ALS ... Guillain-Barre syndrome ... Lambert Eaton Syndrome ... Shellfish poisoning, Meds
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