7 results
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI)

DILI Types:
 • Intrinsic - predictable, dose dependent
presentation • Chronic ... disease 6-9 mo ... Diagnosis #Management #gastroenterology ... #algorithm #gastroenterology ... #hepatology
Commonly Observed Laboratory Findings in Hepatic / Liver Failure
 - Elevated conjugated and unconjugated bilirubin -
Commonly Observed Laboratory ... hepatocytes; in chronic ... liver disease, ... BUN - Decreased urine ... #Laboratory #Diagnosis
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
Stepwise Diagnosis Algorithm ... duration), Several medications ... disease, Hepatic ... e.g. ascites), Chronic ... #hepatology
Nail Disorders secondary to Systemic Diseases
Nail Fold Abnormality
 • SLE
 • Scleroderma
 • Dermatomyositis
Koilonychia - Spoon-shaped
Discoloration • Medications ... discoloration) • Liver ... discoloration) • Chronic ... Systemic #Secondary #dermatology ... Differential #Diagnosis #Algorithm
Autoimmune Hepatitis

Clinical Presentation
 - Highly variable clinical presentation, from subclinical disease to acute liver failure.
 -
from subclinical disease ... to acute liver ... - Symptoms of chronic ... Management - Strong indications ... Necrosis) If mild laboratory
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
and fever) and laboratory ... with: • Minimal laboratory ... edema, active urine ... with Lupus: • Chronic ... activation and/or medications
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases

• Septic arthritis - Gram stain and culture of
more time for the laboratory ... Screening Tests for Chronic ... profile, including liver ... • Serum and urine ... Rheumatoid #Arthritis #laboratory