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Nephritic vs Nephrotic Syndrome

Step 1: If the patient has hematuria and/or proteinuria, think about nephrotic/nephritic syndromes.
Step
the patient have glomerular ... casts or dysmorphic ... RBCs in urine)? ... #Syndrome #Comparison ... #Algorithm #Nephrology
Glomerular Diseases - Nephritic and Nephrotic Syndromes

Nephritic syndrome—due to GBM disruption. 
Hypertension. t BUN and creatinine.
Glomerular Diseases ... hematuria. ... RBC casts in urine ... but in severe cases ... #Proteinuria #Nephrology
Differentiation Between Nephrotic Syndrome and Nephritic Syndrome 
== Nephrotic Syndrome ==
Onset - Insidious 
Edema - ++++
Blood
Proteinuria - ++++ Hematuria ... Red blood cell casts ... Red blood cell casts ... #Comparison #Table ... #Nephrology #Diagnosis
Causes of Hematuria - Differential Diagnosis Algorithm
Red blood cells on urine microscopy. Must exclude false positives
Causes of Hematuria ... blood cells on urine ... RBCs and/or RBC casts ... • Hereditary nephritis ... and >3.5g/day (nephrotic
Hematuria - Differential Diagnosis Framework

Gross Hematuria: Red/Dark urine
 • 1ml blood/liter urine can induce color change
or dipstick) Glomerular ... of Glomerular Bleeding ... • Signs of glomerular ... RBC casts → Diagnostic ... #urology #nephrology
Hematuria Workup and Diagnosis Algorithm
 • Confirm hematuria → Urinalysis >3 RBCs/HPF, exclude mimics, repeat testing
• Evidence of glomerular ... proteinuria, RBC casts ... → Refer to Nephrology ... cystoscopy • Refer to Nephrology ... if cause not identified
Algorithm - Approach to the differential diagnosis of the patient presenting with overt glomerular proteinuria. CMV
cell/white cell casts ... urine sediment ... Nephrocalcinosis causes ... Hematuria may be ... #syndrome #nephrology
Membranoproliferative Glomerulonephritis (MPGN) AKA: Mesangiocapillary GN
 • Active Urine Sediment (dysmorphic RBC, RBC casts, +/- proteinuria)
GN • Active Urine ... dysmorphic RBC, RBC casts ... formation along glomerular ... glomerulopathy, radiation nephritis ... Glomerulonephritis #MPGN #nephrology