11 results
Cerebral Salt Wasting vs SIADH - Pathophysiology 
1) Neurological event
2) Sodium loss from tubules
3) Naturiesis →
Cerebral Salt Wasting ... Neurological event 2) Sodium ... → Increased urine ... diagnosis #nephrology #hyponatremia ... #comparison
Volume Based Approach to Hyponatremia
Hypovolemic, Serum uric acid >4
 • Urine Na <20: Extra-renal losses
 •
Hypovolemic, Serum ... Renal losses, Cerebral ... uric acid <4 • SIADH ... #algorithm #diagnosis ... #sodium #low #nephrology
True Hyponatremia Differential Algorithm

Instead (or in addition) of volume status examination, check urine sodium and serum
Differential Algorithm ... sodium low, uric ... acid high in hypovolemic ... - Urine sodium ... and uric acid low
Modified Hyponatremia Algorithm
Hypertonic Hyponatremia: Hyperglycemia, Mannitol, Urologic irrigants
Hypotonic Hyponatremia: 
 • ADH ON (UOsm > 100):
ON (UNa < 30): Hypovolemia ... OFF (UNa > 30): SIADH ... Reset osmostat, Cerebral ... Primary polydipsia, Low ... #sodium #nephrology
Hyponatremia Differential Diagnosis Algorithm - Utilizing Uric Acid 
ADH promotes Urea/uric acid excretion along with water
Hyponatremia Differential ... Diagnosis Algorithm ... Sodium 4) Serum ... Uric Acid → SIADH ... #low #uricacid
Physiologic Approach to Hypotonic Hyponatremia
The next time you have a case of hypotonic hyponatremia, give the
normal volume-based algorithm ... Urine Na+K / serum ... , Renal Sodium loss ... can be high or low ... Insufficiency, Cerebral
Hyponatremia - Differential Algorithm
Isotonic Hyponatremia: Hyperlipidemia, Hyperproteinemia, Recent TURP
Hypotonic Hyponatremia: 
 • Hypovolemia: Diuretics/Nephropathies, Vomiting, Diarrhea,
Algorithm Isotonic ... : • Hypovolemia ... • Euvolemia: SIADH ... causes #nephrology #sodium ... #low
Hypernatremia - Differential Diagnosis Workup Algorithm

1) Check Urine Osmolality:
 > 600 mOsm/kg - Implies extrarenal mechanism
Diagnosis Workup Algorithm ... 1) Check Urine ... : • Hypovolemic ... • Euvolemic (Low ... #nephrology #sodium
Hyponatremia (<135 mEq/L) is a common electrolyte abnormality caused by an excess of total body water
body water in comparison ... consequence of cerebral ... Measured urine sodium ... #RAAS #Hypovolemia ... EBV #potomania #SIADH
A lazy man's classification of hyponatremia
There are two possible approaches to the diagnosis of hyponatremia: .
serum osmolality, urine ... osmolality and urinary sodium ... the patient has SIADH ... or cerebral salt ... #Algorithm #Differential