246 results
Type I Hypersensitivity: Pathogenesis and clinical findings
Definition: Production of lgE Antibodies that bind to harmless allergens
leading to an allergic ... Sensitization" to Allergen ... pollen & dust) • Urticaria ... (hives) • Allergic ... conjunctivitis • Anaphylaxis
Clinical manifestations of anaphylaxis. 
Neurological (<15%): Dizziness, syncope, seizures, Confusion, impending doom. headache
Angioedema: Lips, tongue, orbit,
manifestations of anaphylaxis ... Mucosa 80-90%): Urticaria ... incontinence #anaphylaxis ... diagnosis #criteria #allergy
Anaphylaxis: Signs and Symptoms
Anaphylaxis: when any egg of three conditions is met:
1. Acute onset of skin/mucosal
Anaphylaxis: Signs ... and Symptoms Anaphylaxis ... exposure to a likely allergen ... exposure to known allergen ... ischemia) • Urticaria
Penicillin Allergy Pathway for Antibiotic Prescription in Patients With Penicillin Allergy
Mild Reaction - Itching, Minor rash
Penicillin Allergy ... With Penicillin Allergy ... HSR), EMR lists allergy ... lgE-Mediated) HSR - Anaphylaxis ... Hypotension, Hives/urticaria
Manifestations of Anaphylaxis by Body System

Dermatologic/mucosal

 - Eyes: periorbital swelling/erythema, injected conjunctiva, tears

 - Oral mucosa:
Manifestations of Anaphylaxis ... lips - Skin: urticarial ... play #Diagnosis #Allergy ... Signs #Symptoms #Anaphylaxis
Approach to Elevated Tryptase - Differential Diagnosis Framework

The DDx of elevated tryptase can be broken down
secondary causes: • Anaphylaxis ... infections • Chronic Urticaria ... Diagnosis #hematology #allergy
Drug Treatment of Anaphylaxis and Allergic Reactions
First-Line Therapy 
 - Epinephrine 
 - Oxygen 
 -
Drug Treatment of Anaphylaxis ... and Allergic Reactions ... Prednisone #Anaphylaxis ... #Medications #Allergy
Pediatric Anaphylaxis Algorithm 

#Anaphylaxis #Algorithm #Pediatrics #Peds #Allergy
Pediatric Anaphylaxis ... Algorithm #Anaphylaxis ... Pediatrics #Peds #Allergy
Angioedema - Classification Diagnosis and Treatment
Types of Angioedema:
 • Acute allergic angioedema - Usually occurs with
Angioedema: • Acute allergic ... Usually occurs with urticaria ... exposure • Non-allergic ... usually occurs with urticaria ... or avoiding the allergen
Hypersensitivity: Summary
Type I Hypersensitivity:
 • Immunological Mediator: lgE
 • Immunological Target: Allergen Molecules
 • Ex: Antibiotic
Immunological Target: Allergen ... peanuts), Hay fever, Urticaria ... , Allergic conjunctivitis ... Hypersensitivity #Allergy ... #Allergic #Reactions