15 results
Glomerular Diseases - Nephritic and Nephrotic Syndromes

Nephritic syndrome—due to GBM disruption. 
Hypertension. t BUN and creatinine.
Glomerular Diseases ... to GBM disruption ... Proteinuria often ... Massive proteinuria ... #Nephrology #Diagnosis
Nephritic vs Nephrotic Syndrome

Step 1: If the patient has hematuria and/or proteinuria, think about nephrotic/nephritic syndromes.
Step
Nephritic vs Nephrotic ... hematuria and/or proteinuria ... the patient have glomerular ... #Nephritic #Nephrotic ... Comparison #Algorithm #Nephrology
Glomerular Diseases - Spectrum
 - Insidious vs Acute
 - Nephritic (hypertension, hematuria, renal failure) vs Nephrotic
Glomerular Diseases ... Insidious vs Acute - Nephritic ... renal failure) vs Nephrotic ... (Heavy proteinuria ... differential #diagnosis #nephrology
Spectrum of Glomerular Diseases
Nephrotic - Mechanism:
 • Injury to podocytes
 • Changed architecture: Scanning. Deposition of
Spectrum of Glomerular ... • Breaks in GBM ... formation #Glomerular ... spectrum #diagnosis #nephrology ... #nephritic #nephrotic
Algorithm - Approach to the differential diagnosis of the patient presenting with overt glomerular proteinuria. CMV
proteinuria. ... Cytomegalovirus; GBM ... clusters because nephritic ... #proteinuria #nephrotic ... #syndrome #nephrology
Rapidly Progressive Glomerulonephritis (RPGN) 
 - Loss of kidney function over a short period of tirne
with evidence of glomerular ... disease (hematuria, proteinuria ... nephropathy, lupus nephritis ... post-infectious GN Anti-Glomerular ... Differential #Diagnosis #Nephrology
Causes of Hematuria - Differential Diagnosis Algorithm
Red blood cells on urine microscopy. Must exclude false positives
nephropathy • Thin GBM ... • Hereditary nephritis ... ) • Anti-GBM ... and >3.5g/day (nephrotic ... range) proteinuria
Recommended initial testing for patients being evaluated for glomerular disease 

24-hour urine collection - Quantify proteinuria.
proteinuria. ... once the total proteinuria ... So, proteinuria ... glomerulonephritis #nephrotic ... #nephritic #nephrology
Causes of Proteinuria - Differential Diagnosis Algorithm
Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
Causes of Proteinuria ... • Drugs Glomerular ... Proteinuria (Positive ... proliferative • Anti-GBM ... #Nephrology #Differential
Summary of characteristic abnormalities of selected glomerular diseases
Light Microscopy (LM) - Immunofluorescence Microscopy (IM) - Electron
Immunofluorescence Microscopy (IM ... ) Haematuria/nephritis ... Haemolytic-uraemic syndrome Nephrotic ... RPGN • Anti-GBM ... #diseases #nephrology