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diagnosis differential causes acute aki algorithm hematuria kidney rheumatology urine vasculitis antigbm atlas basement blood casts classification comparison disease glomerulonephritis
Summary of characteristic abnormalities of selected glomerular diseases Light Microscopy (LM) - Immunofluorescence Microscopy (IM) - Electron
abnormalities of selected glomerular ... Microscopy (EM) ... Amyloid RPGN • Anti-GBM ... polyangiitis #glomerular ... #diseases #nephrology
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
Pulmonary Renal ... polyangiitis, Microscopic ... sclerosis • Anti-Glomerular ... ab, anti-GBM ab ... differential #diagnosis #nephrology
Causes of acute kidney injury (AKI). AKI is classified into pre-renal, renal, and post-renal causes. Renal
of acute kidney injury ... vascular supply; glomerular ... and interstitial disease ... GBM, Glomerular ... Causes #Sites #Nephrology
Acute Kidney Injury (AKI) - Differential Diagnosis Framework PRE-Renal AKI: • Hypovolemia • Congestion • Medications •
Acute Kidney Injury ... • Vascular • Glomerular ... Immune-complex disease ... , Anti-GBM • Tubular ... Differential #Diagnosis #nephrology
Atlas of Urine Microscopy Findings • Epithelial cells - Normal • Renal tubular cells - Acute
Acute tubular injury ... red - cells Non-glomerular ... Dysmorphic red cells - Glomerular ... Diagnostic of glomerular ... key #diagnosis #nephrology
Anti-GIomeruIar Basement Membrane Disease (Goodpasture's Disease) What is it? A small vessel vasculitis with circulating antibodies directed
Anti-GIomeruIar ... directed against the glomerular ... Diagnosis: • Anti-GBM ... #GIomeruIar #Basement ... #pulmonary
Causes of Hematuria - Differential Diagnosis Algorithm Red blood cells on urine microscopy. Must exclude false positives
cells on urine microscopy ... • Calculi Glomerular ... epithelial side of glomerular ... endothelial side of glomerular ... wall) • Anti-GBM
Hematuria - Differential Diagnosis Framework Gross Hematuria: Red/Dark urine • 1ml blood/liter urine can induce color change
or dipstick) Glomerular ... • Causes of Glomerular ... hematuria • Signs of glomerular ... Suggestive of glomerular ... disease Renal
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
Pulmonary Renal ... injury), Coags ... ANCA antibody, Anti-GBM ... usually low in anti-GBM ... hypercellular glomeruli
Causes of Proteinuria - Differential Diagnosis Algorithm Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
• Drugs Glomerular ... proliferative • Anti-GBM ... polyangiitis (GPA) / microscopic ... Minimal change disease ... #Proteinuria #Nephrology
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