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diagnosis pathology clinical differential electronmicroscopy glomerular glomerulus pulmonary glomerulonephritis renal tuft antigbm classification comparison diseases giomeruiar goodpastures management membranous mgn
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
polyangiitis, Microscopic ... Basement Membrane ... ab, anti-GBM ab ... biopsy By Tess Litchman ... differential #diagnosis #nephrology
Anti-GIomeruIar Basement Membrane Disease (Goodpasture's Disease) What is it? A small vessel vasculitis with circulating antibodies directed
Basement Membrane ... basement membrane ... Diagnosis: • Anti-GBM ... #Membrane #Disease ... AntiGBM #diagnosis #nephrology
Rapidly Progressive Glomerulonephritis (RPGN) - Loss of kidney function over a short period of tirne
of glomerular disease ... Basement Membrane ... staining on IF • No EM ... + • c-ANCA: anti-proteinase ... Differential #Diagnosis #Nephrology
Summary of characteristic abnormalities of selected glomerular diseases Light Microscopy (LM) - Immunofluorescence Microscopy (IM) - Electron
selected glomerular diseases ... (IM) - Electron ... Microscopy (EM) ... Amyloid RPGN • Anti-GBM ... #nephrology #pathology
Glomerular Tuft on Electron Microscopy This eyeSCANdy image shows acellular scanning EM of a normal glomerular tuft
Tuft on Electron Microscopy ... acellular scanning EM ... capillary loop basement ... membranes following ... #clinical #nephrology
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 Glomerular Tuft on Electron Microscopy This eyeSCANdy image shows acellular scanning EM of a normal glomerular tuft
Tuft on Electron Microscopy ... acellular scanning EM ... capillary loop basement ... membranes following ... #clinical #nephrology
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 Stage IV Glomerulonephritis on Electron Microscopy This image shows acellular scanning EM of glomerular capillary loops from
acellular scanning EM ... second layer of basement ... membrane response ... ElectronMicroscopy #SEM ... #clinical #nephrology
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 Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
polyangiitis) Anti-basement ... membrane: Goodpasture ... life-threatening diseases ... ANCA antibody, Anti-GBM ... usually low in anti-GBM
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