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diagnosis differential pulmonary antibodies antibody antinuclear classification diseases glomerulonephritis management prs rheumatology rpgn syndrome syndromes treatment
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
(Antineutrophil ... Anti-Sm (Smith) ... Vasculitis: • Microscopic ... + 90% • Anti-GBM ... #Antineutrophil
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
Pauci-Immune: - ANCA-positive ... polyangiitis) - ANCA-negative ... testing: anti-ANCA ... ab, anti-GBM ab ... , ANA, C3, C4, anti-CCP
Rapidly Progressive Glomerulonephritis (RPGN) - Loss of kidney function over a short period of tirne
of glomerular disease ... staining on IF • No EM ... cytoplasmic antibody (ANCA ... ) + • c-ANCA: ... staining • p-ANCA
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
Summary Autoimmune ANCA ... membrane: Goodpasture ... Auto-antibodies: ANCA ... antibody, Anti-GBM ... usually low in anti-GBM
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