5 results
Pulmonary Renal Syndrome

Definition: Diffuse alveolar hemorrhage + Glomerulonephritis
Presentation (Pulmonary and renal manifestations can occur weeks apart):
polyangiitis, Microscopic ... Basement Membrane ... ab, anti-GBM ab ... biopsy By Tess Litchman ... #diagnosis #nephrology
Summary of characteristic abnormalities of selected glomerular diseases
Light Microscopy (LM) - Immunofluorescence Microscopy (IM) - Electron
(IM) - Electron ... Microscopy (EM) ... Amyloid RPGN • Anti-GBM ... #nephrology #pathology ... #comparison #table
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
 • Systemic lupus erythematosus
   1. Anti-dsDNA
Anti-Sm (Smith) ... cases • Sjögren syndrome ... Vasculitis: • Microscopic ... polyangiitis without renal ... ANCA+ 90% • Anti-GBM
Pulmonary Renal Syndromes - OnePager Summary
Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
membrane: Goodpasture ... life-threatening diseases ... Inflammatory eye disease ... ANCA antibody, Anti-GBM ... usually low in anti-GBM
Membranoproliferative Glomerulonephritis (MPGN) AKA: Mesangiocapillary GN
 • Active Urine Sediment (dysmorphic RBC, RBC casts, +/- proteinuria)
(Dense deposit disease ... immune deposits on EM ... syndrome, post-bone ... Glomerulonephritis #MPGN #nephrology ... #diagnosis #renal