13 results
Summary of characteristic abnormalities of selected glomerular diseases
Light Microscopy (LM) - Immunofluorescence Microscopy (IM) - Electron
selected glomerular diseases ... Microscopy (EM) ... Minimal change disease ... Amyloid RPGN • Anti-GBM ... #diagnosis #microscopy
Pulmonary Renal Syndrome

Definition: Diffuse alveolar hemorrhage + Glomerulonephritis
Presentation (Pulmonary and renal manifestations can occur weeks apart):
Peripheral edema, Disease-specific ... vasculitis, Behcet disease ... Goodpasture's Disease ... dysmorphic RBCs) • Disease-specific ... ab, anti-GBM ab
Causes of acute kidney injury (AKI). AKI is classified into pre-renal, renal, and post-renal causes. Renal
and interstitial disease ... GBM, Glomerular ... basement membrane ... #Diagnosis #AKI ... Causes #Sites #Nephrology
Anti-GIomeruIar Basement Membrane Disease (Goodpasture's Disease)

What is it? A small vessel vasculitis with circulating antibodies directed
Disease (Goodpasture's ... Disease) What ... : • Anti-GBM antibodies ... #Membrane #Disease ... #nephrology #pulmonary
Spectrum of Glomerular Diseases
Nephrotic - Mechanism:
 • Injury to podocytes
 • Changed architecture: Scanning. Deposition of
of Glomerular Diseases ... Mechanism: • Injury ... #Glomerular #Diseases ... #nephrology #nephritic ... #nephrotic #comparison
Rapidly Progressive Glomerulonephritis (RPGN) 
 - Loss of kidney function over a short period of tirne
of glomerular disease ... Basement Membrane ... + • c-ANCA: anti-proteinase ... #Differential #Diagnosis ... #Nephrology
Acute Kidney Injury (AKI) - Differential Diagnosis Framework

PRE-Renal AKI:
 • Hypovolemia
 • Congestion
 • Medications
 •
Acute Kidney Injury ... Immune-complex disease ... , Anti-GBM • Tubular ... Bilateral ureteral disease ... #nephrology
Causes of Hematuria - Differential Diagnosis Algorithm
Red blood cells on urine microscopy. Must exclude false positives
- Differential Diagnosis ... cells on urine microscopy ... disease • ... wall) • Anti-GBM ... • Pauci-immune disease
Pulmonary Renal Syndromes - OnePager Summary
Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
polyangiitis) Anti-basement ... life-threatening diseases ... Inflammatory eye disease ... ANCA antibody, Anti-GBM ... usually low in anti-GBM
Hematuria - Differential Diagnosis Framework

Gross Hematuria: Red/Dark urine
 • 1ml blood/liter urine can induce color change
Immune mediated injury ... nephropathy - Thin basement ... membrane disease ... of glomerular disease ... causes #urology #nephrology