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diagnosis differential pathology clinical electronmicroscopy glomerulonephritis membranous sem renal rheumatology vasculitis algorithm anti antigbm basement causes classification comparison disease diseases
Summary of characteristic abnormalities of selected glomerular diseases Light Microscopy (LM) - Immunofluorescence Microscopy (IM) - Electron
(IM) - Electron ... Microscopy (EM) ... Post-infectious GN ... RPGN • Anti-GBM ... glomerular #diseases #nephrology
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
Pulmonary Renal ... polyangiitis, Microscopic ... anti-ANCA ab, anti-GBM ... biopsy By Tess Litchman ... differential #diagnosis #nephrology
Stage III Glomerulonephritis on Electron Microscopy This image shows acellular scanning EM from a biopsy with membranous
more extensive GBM ... surface of reticular GBM ... glomerulonephritis #MGN ... #stage3 #GBM #ElectronMicroscopy ... SEM #clinical #nephrology
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 Stage II Membranous Glomerulonephritis on Electron Microscopy This eyeSCANdy image shows acellular scanning EM of a glomerulus
Glomerulonephritis on Electron Microscopy ... appearance of GBM ... glomerulonephritis #MGN ... #stage2 #GBM #ElectronMicroscopy ... SEM #clinical #nephrology
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 Causes of Proteinuria - Differential Diagnosis Algorithm Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
Membranoproliferative GN ... proliferative • Anti-GBM ... polyangiitis (GPA) / microscopic ... Post-infectious GN ... #Proteinuria #Nephrology
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
polyangiitis), MPA (microscopic ... antibody, Anti-GBM ... usually low in anti-GBM ... FINDINGS: • U/A: microscopic ... in crescentic GN
Stage IV Glomerulonephritis on Electron Microscopy This image shows acellular scanning EM of glomerular capillary loops from
Glomerulonephritis on Electron Microscopy ... acellular scanning EM ... completely bridged GBM ... glomerulonephritis #glomerulus #MGN ... SEM #clinical #nephrology
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 Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
rapidly progressing GN ... • New pulmonary ... PR3-ANCA): • Microscopic ... glomerulonephritis) • Anti-GBM ... Dx: GPA, EGPA, microscopic
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
• New pulmonary ... (PR3-ANCA)): Microscopic ... MPO > PR3) • Pulmonary ... Granulomas, IgE, pulmonary ... Anti-GBM (10 -
Anti-GIomeruIar Basement Membrane Disease (Goodpasture's Disease) What is it? A small vessel vasculitis with circulating antibodies directed
Diagnosis: • Anti-GBM ... weeks By Tess Litchman ... AntiGBM #diagnosis #nephrology ... #pulmonary
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