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diagnosis differential glomerulonephritis pathology renal anti antigbm classification clinical comparison disease electronmicroscopy giomeruiar glomerular glomerulus goodpastures management membrane membranous mgn
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
polyangiitis, Microscopic ... Anti-Glomerular Basement ... anti-ANCA ab, anti-GBM ... biopsy By Tess Litchman ... differential #diagnosis #nephrology
Summary of characteristic abnormalities of selected glomerular diseases Light Microscopy (LM) - Immunofluorescence Microscopy (IM) - Electron
selected glomerular diseases ... (IM) - Electron ... Microscopy (EM) ... RPGN • Anti-GBM ... #nephrology #pathology
Rapidly Progressive Glomerulonephritis (RPGN) - Loss of kidney function over a short period of tirne
of glomerular disease ... Anti-Glomerular Basement ... Membrane (GBM) ... Linear, ribbon-like GBM ... staining on IF • No EM
Anti-GIomeruIar Basement Membrane Disease (Goodpasture's Disease) What is it? A small vessel vasculitis with circulating antibodies directed
Membrane Disease ... Diagnosis: • Anti-GBM ... weeks By Tess Litchman ... AntiGBM #diagnosis #nephrology ... #pulmonary
Stage IV Glomerulonephritis on Electron Microscopy This image shows acellular scanning EM of glomerular capillary loops from
acellular scanning EM ... second layer of basement ... completely bridged GBM ... ElectronMicroscopy #SEM ... #clinical #nephrology
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 Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
polyangiitis) Anti-basement ... life-threatening diseases ... Inflammatory eye disease ... antibody, Anti-GBM ... usually low in anti-GBM
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