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diagnosis differential glomerulonephritis pathology renal anti antigbm basement classification clinical comparison disease electronmicroscopy giomeruiar glomerular glomerulus goodpastures management membranous mgn
Summary of characteristic abnormalities of selected glomerular diseases Light Microscopy (LM) - Immunofluorescence Microscopy (IM) - Electron
selected glomerular diseases ... (IM) - Electron ... Microscopy (EM) ... RPGN • Anti-GBM ... #nephrology #pathology
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
polyangiitis, Microscopic ... Anti-Glomerular Basement Membrane ... anti-ANCA ab, anti-GBM ... biopsy By Tess Litchman ... differential #diagnosis #nephrology
Rapidly Progressive Glomerulonephritis (RPGN) - Loss of kidney function over a short period of tirne
of glomerular disease ... Anti-Glomerular Basement Membrane ... (GBM) • Typically ... Linear, ribbon-like GBM ... staining on IF • No EM
Stage IV Glomerulonephritis on Electron Microscopy This image shows acellular scanning EM of glomerular capillary loops from
acellular scanning EM ... layer of basement membrane ... completely bridged GBM ... ElectronMicroscopy #SEM ... #clinical #nephrology
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 Anti-GIomeruIar Basement Membrane Disease (Goodpasture's Disease) What is it? A small vessel vasculitis with circulating antibodies directed
Disease) What ... Diagnosis: • Anti-GBM ... weeks By Tess Litchman ... AntiGBM #diagnosis #nephrology ... #pulmonary
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
Anti-basement membrane ... life-threatening diseases ... Inflammatory eye disease ... antibody, Anti-GBM ... usually low in anti-GBM
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