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diagnosis differential glomerulonephritis pathology algorithm classification clinical electronmicroscopy membranous pulmonary renal rheumatology sem syndrome vasculitis causes comparison diseases glomerulus management
Causes of Proteinuria - Differential Diagnosis Algorithm Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
• Drugs Glomerular ... proliferative • Anti-GBM ... polyangiitis (GPA) / microscopic ... Post-infectious GN ... #Nephrology #Differential
Rapidly Progressive Glomerulonephritis (RPGN) - Loss of kidney function over a short period of tirne
disease (hematuria, proteinuria ... post-infectious GN ... Basement Membrane (GBM ... Linear, ribbon-like GBM ... Differential #Diagnosis #Nephrology
Summary of characteristic abnormalities of selected glomerular diseases Light Microscopy (LM) - Immunofluorescence Microscopy (IM) - Electron
abnormalities of selected glomerular ... (IM) - Electron ... Microscopy (EM) ... RPGN • Anti-GBM ... #diseases #nephrology
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
polyangiitis, Microscopic ... sclerosis • Anti-Glomerular ... • Urinalysis (proteinuria ... anti-ANCA ab, anti-GBM ... differential #diagnosis #nephrology
Algorithm - Approach to the differential diagnosis of the patient presenting with overt glomerular proteinuria. CMV
proteinuria. ... Cytomegalovirus; GBM ... = glomerular basement ... membrane; GN = ... #syndrome #nephrology
Stage II Membranous Glomerulonephritis on Electron Microscopy This eyeSCANdy image shows acellular scanning EM of a glomerulus
of a glomerulus ... appearance of GBM ... glomerulonephritis #MGN ... #stage2 #GBM #ElectronMicroscopy ... SEM #clinical #nephrology
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 Stage IV Glomerulonephritis on Electron Microscopy This image shows acellular scanning EM of glomerular capillary loops from
Glomerulonephritis on Electron Microscopy ... of glomerular capillary ... completely bridged GBM ... #MGN #stage4 #ElectronMicroscopy ... SEM #clinical #nephrology
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 Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
polyangiitis), MPA (microscopic ... antibody, Anti-GBM ... usually low in anti-GBM ... hypercellular glomeruli ... in crescentic GN
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
• Hematuria, proteinuria ... rapidly progressing GN ... PR3-ANCA): • Microscopic ... glomerulonephritis) • Anti-GBM ... : - Kidneys: glomerular
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
• Hematuria, proteinuria ... Rapidly progressing GN ... • Kidneys: Non-glomerular ... (PR3-ANCA)): Microscopic ... Anti-GBM (10 -
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