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V/Q Mismatch Physiology

by Dr. Lizzy Hastie @LizzyHastie

#VQMismatch #pathophysiology #diagnosis #pulmonary
V/Q Mismatch Physiology ... LizzyHastie #VQMismatch
Hypoxemia Differential Diagnosis Algorithm by A-a Gradient

Normal A-a Gradient:
 • ↓ Atmospheric pressure
 • Hypoventilation: CNS
Alveolar • V/Q Mismatch ... Algorithm #pulmonary #Aa
Amyloidosis Types - Comparison Table
Proteins depositing where they shouldn't
 • AL
 • TTR
 • AA

Julia Gips,
AL • TTR • AA
Aplastic Anemia Summary

 • Definition
 • Pathophysiology
 • DDx: AA vs Hypocellular MDS
 • Expectation
 •
Pathophysiology • DDx: AA
Approach to the A-a Gradient
A-a gradient = PAO2 - PaO2
A-a gradient = [FiO2 x (Patm -
and more • V/Q Mismatch ... UnremarkableLab #AA
Amyloidosis - Summary
Group of disorders associated with extracellular deposition of fibrils formed from low-molecular-weight proteins in
Secondary amyloid A (AA ... nephropathy is common in AA ... light chain AA ... IL-1 & IL-6 → AA
Lynch Syndrome:
 • "CRC + Endometrial/Ovarian + Stomach + Urinary → Lynch Syndrome"
 • Autosomal Dominant,
EPCAM genes → Mismatch
Causes of Hypoxemia- Differential Diagnosis Algorithm
Ventilation/perfusion Mismatch
 • Airway Disease (Asthma, COPD)
 • Vascular (PE*)
 •
Ventilation/perfusion Mismatch
Hypoxemic Respiratory Failure - Differential Diagnosis Framework
DECREASED INSPIRED OXYGEN
 • Low PATM Can decrease first part
common than VIQ mismatch ... PERFUSION (V/Q) MISMATCH
Treatment of Alcohol Use Disorder

Treatment options for AUD include psychosocial treatment and medications. Individualize based on
support groups (AA