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V/Q Mismatch Physiology

by Dr. Lizzy Hastie @LizzyHastie

#VQMismatch #pathophysiology #diagnosis #pulmonary
V/Q Mismatch Physiology ... LizzyHastie #VQMismatch
Hypoxemic Respiratory Failure - Differential Diagnosis Framework
DECREASED INSPIRED OXYGEN
 • Low PATM Can decrease first part
gas equation • Causes ... obesity-hypoventilation syndrome ... common than VIQ mismatch ... PERFUSION (V/Q) MISMATCH ... hepatopulmonary syndrome
Causes of Erythema Nodosum - Mnemonic

NO cause found in 60% of cases
Drugs (antibiotics e.g., sulfonamides, amoxicillin)
Oral
Causes of Erythema ... Mnemonic NO cause ... found in 60% of cases ... Sarcoidosis or Lofgren's syndrome ... Nodosum #Mnemonic #Causes
Causes of Hypoxemia- Differential Diagnosis Algorithm
Ventilation/perfusion Mismatch
 • Airway Disease (Asthma, COPD)
 • Vascular (PE*)
 •
Causes of Hypoxemia ... Ventilation/perfusion Mismatch ... Hypoventilation Syndrome ... Diagnosis #Algorithm #Causes
Hyperthermic Syndromes - This table summarizes the similarities and differences between some toxicologic causes of hyperthermic
Hyperthermic Syndromes ... some toxicologic causes ... of hyperthermic syndromes ... • Serotonin syndrome ... #Hyperthermic #Syndromes
Glomerular Diseases - Nephritic and Nephrotic Syndromes

Nephritic syndrome—due to GBM disruption. 
Hypertension. t BUN and creatinine.
and Nephrotic Syndromes ... Nephritic syndrome—due ... RBC casts in urine ... but in severe cases ... Nephritic #Nephrotic #Syndromes
Causes of Metabolic Alkalosis - Differential Diagnosis
Chloride depletion syndromes
 • Gastrointestinal losses
    -
Causes of Metabolic ... Chloride depletion syndromes ... • Liddle syndrome ... administration Other causes ... Differential #Diagnosis #Causes
Budd Chiari Syndrome
Hepatic vein obstruction. Can be caused by thrombosis or sometimes a tumour. Can lead
Budd Chiari Syndrome ... Can be caused by ... #BuddChiari #Syndrome ... #Diagnosis #Causes
Causes of Small Bowel Bleeding - Differential Diagnosis
Common Causes:
 • Under age 40 years: Inflammatory Bowel
Causes of Small ... Diagnosis Common Causes ... NSAID ulcers Rare Causes ... , Inherited syndromes ... Differential #Diagnosis #Causes
Lynch Syndrome:
 • "CRC + Endometrial/Ovarian + Stomach + Urinary → Lynch Syndrome"
 • Autosomal Dominant,
Lynch Syndrome: ... Urinary → Lynch Syndrome ... EPCAM genes → Mismatch ... DeanEhrlich_MD #Lynch #Syndrome